|Application ||WB, E|
|Other Accession||P63035, P63034, Q2KI41, NP_004219.3|
|Calculated MW||46546 Da|
|Antigen Region||36-64 aa|
|Other Names||Cytohesin-2, ARF exchange factor, ARF nucleotide-binding site opener, Protein ARNO, PH, SEC7 and coiled-coil domain-containing protein 2, CYTH2, ARNO, PSCD2, PSCD2L|
|Target/Specificity||This PSCD2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 36-64 amino acids from the N-terminal region of human PSCD2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PSCD2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||ARNO, PSCD2, PSCD2L|
|Function||Acts as a guanine-nucleotide exchange factor (GEF). Promotes guanine-nucleotide exchange on ARF1, ARF3 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. The cell membrane form, in association with ARL4 proteins, recruits ARF6 to the plasma membrane.|
|Cellular Location||Cell membrane; Peripheral membrane protein Cytoplasm. Note=Both isoform 1 and isoform 2 are recruited to the cell membrane through their association with ARL4A, ARL4C and ARL4D. They require also interaction with phosphoinositides for targeting to the plasma membrane|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. The encoded protein exhibits GEP activity in vitro with ARF1, ARF3, and ARF6 and is 83% homologous to CYTH1. Two transcript variants encoding different isoforms have been found for this gene.
Merkulova, M., et al. Biochim. Biophys. Acta 1797(8):1398-1409(2010)
Torii, T., et al. J. Biol. Chem. 285(31):24270-24281(2010)
White, D.T., et al. Mol. Biol. Cell 21(4):562-571(2010)
Bouschet, T., et al. J. Cell. Sci. 120 (PT 15), 2489-2497 (2007) :
Wu, C., et al. Proteomics 7(11):1775-1785(2007)
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