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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   PSCD2 Antibody (N-term)   

PSCD2 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - PSCD2 Antibody (N-term) AP12239A
    PSCD2 Antibody (N-term) (Cat. #AP12239a) western blot analysis in mouse kidney tissue lysates (35ug/lane).This demonstrates the PSCD2 antibody detected the PSCD2 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q99418
Other Accession P63035, P63034, Q2KI41, NP_004219.3
Reactivity Mouse
Predicted Bovine, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 46546 Da
Antigen Region 36-64 aa
Additional Information
Gene ID 9266
Other Names Cytohesin-2, ARF exchange factor, ARF nucleotide-binding site opener, Protein ARNO, PH, SEC7 and coiled-coil domain-containing protein 2, CYTH2, ARNO, PSCD2, PSCD2L
Target/Specificity This PSCD2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 36-64 amino acids from the N-terminal region of human PSCD2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPSCD2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CYTH2
Synonyms ARNO, PSCD2, PSCD2L
Function Acts as a guanine-nucleotide exchange factor (GEF). Promotes guanine-nucleotide exchange on ARF1, ARF3 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. The cell membrane form, in association with ARL4 proteins, recruits ARF6 to the plasma membrane.
Cellular Location Cell membrane; Peripheral membrane protein Cytoplasm. Note=Both isoform 1 and isoform 2 are recruited to the cell membrane through their association with ARL4A, ARL4C and ARL4D. They require also interaction with phosphoinositides for targeting to the plasma membrane
Tissue Location Ubiquitous.
Research Areas
Citations (0)

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The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. The encoded protein exhibits GEP activity in vitro with ARF1, ARF3, and ARF6 and is 83% homologous to CYTH1. Two transcript variants encoding different isoforms have been found for this gene.


Merkulova, M., et al. Biochim. Biophys. Acta 1797(8):1398-1409(2010)
Torii, T., et al. J. Biol. Chem. 285(31):24270-24281(2010)
White, D.T., et al. Mol. Biol. Cell 21(4):562-571(2010)
Bouschet, T., et al. J. Cell. Sci. 120 (PT 15), 2489-2497 (2007) :
Wu, C., et al. Proteomics 7(11):1775-1785(2007)

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$ 295.00
$ 99.00
Cat# AP12239A
(40 western blots)
Availability: In Stock
Bulk Size
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