|Application ||WB, FC, E|
|Other Accession||Q5M9G6, Q8BIZ6, NP_078976.2|
|Calculated MW||45778 Da|
|Antigen Region||91-118 aa|
|Other Names||Smad nuclear-interacting protein 1, FHA domain-containing protein SNIP1, SNIP1|
|Target/Specificity||This SNIP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 91-118 amino acids from the N-terminal region of human SNIP1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SNIP1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Down-regulates NF-kappa-B signaling by competing with RELA for CREBBP/EP300 binding. Involved in the microRNA (miRNA) biogenesis. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA.|
|Tissue Location||Ubiquitous, with highest expression in heart and skeletal muscle.|
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Provided below are standard protocols that you may find useful for product applications.
Down-regulates NF-kappa-B signaling by competing with RELA for CREBBP/EP300 binding. SNIP1 is involved in the microRNA (miRNA) biogenesis.
Bracken, C.P., et al. Cancer Res. 68(18):7621-7628(2008)
Yu, B., et al. Proc. Natl. Acad. Sci. U.S.A. 105(29):10073-10078(2008)
Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)
Matsuoka, S., et al. Science 316(5828):1160-1166(2007)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
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