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ARHB Antibody (Center)Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP12264c | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
| AP12264c-ev20 | 20 ug 100 ul | In Stock | $ 95.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
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- Backgrounds
ARHB Antibody (Center) - Product info | |
| Application | WB, IHC
|
| Primary Accession | P62745 |
| Other Accession | P62747, P62746, Q3ZBW5, NP_004031.1 |
| Reactivity | Human |
| Predicted | Bovine, Mouse, Rat |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 22123 Da |
ARHB Antibody (Center) - Additional info | |
| Gene ID 388 | |
| Other Names RHOB; ARH6; ARHB; Rho-related GTP-binding protein RhoB; Rho cDNA clone 6 | |
| Target/Specificity This ARHB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 103-137 amino acids from the Central region of human ARHB. | |
| Dilution WB~~1:50~100WB~~1:1000 IHC~~1:10~50 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions ARHB Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. | |
ARHB Antibody (Center) - Protein Information | |
| Name RHOB | |
| Synonyms ARH6, ARHB | |
| Function Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation Involved in intracellular protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis Required for genotoxic stress-induced cell death in breast cancer cells | |
| Cellular Location Late endosome membrane; Lipid-anchor. Cell membrane; Lipid-anchor. Nucleus. Cleavage furrow. Note=Late endosomal membrane (geranylgeranylated form). Plasma membrane (farnesylated form). Also detected at the nuclear margin and in the nucleus. Translocates to the equatorial region before furrow formation in a ECT2-dependent manner | |
ARHB Antibody (Center) - Related products
ARHB Antibody (Center) - Application data
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ARHB Antibody (Center) (Cat. #AP12264c) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the ARHB antibody detected the ARHB protein (arrow).
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ARHB Antibody (Center) (Cat. #AP12264c)immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of ARHB Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
ARHB Antibody (Center) - Research Areas
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BACKGROUND
ARHB mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development.
REFERENCES
Adly, M.A., et al. J. Cutan. Pathol. 37(7):751-757(2010) Connolly, E.C., et al. Mol. Cancer Res. 8(5):691-700(2010) Zintzaras, E., et al. Am. J. Epidemiol. 171(8):851-858(2010) Kim, C.H., et al. Biochem. Biophys. Res. Commun. 391(2):1182-1186(2010) Takefuji, M., et al. J. Hum. Genet. 55(1):42-49(2010)
