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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   TPSAB1 Antibody (C-term)   

TPSAB1 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - TPSAB1 Antibody (C-term) AP12270b
    TPSAB1 Antibody (C-term) (Cat. #AP12270b) western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the TPSAB1 antibody detected the TPSAB1 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q15661
Other Accession P20231, NP_003285
Reactivity Mouse
Predicted Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 30515 Da
Antigen Region 249-275 aa
Additional Information
Gene ID 7177
Other Names Tryptase alpha/beta-1, Tryptase-1, Tryptase I, Tryptase alpha-1, TPSAB1, TPS1, TPS2, TPSB1
Target/Specificity This TPSAB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 249-275 amino acids from the C-terminal region of human TPSAB1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTPSAB1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms TPS1, TPS2, TPSB1
Function Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type.
Cellular Location Secreted. Note=Released from the secretory granules upon mast cell activation.
Research Areas
Citations (0)

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Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. The alleles of this gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate genes, alpha and beta 1. Beta tryptases appear to be the main isoenzymes expressed in mast cells; whereas in basophils, alpha tryptases predominate. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders.


Lee, J.W., et al. Dig. Dis. Sci. 55(10):2922-2928(2010)
Trivedi, N.N., et al. J. Allergy Clin. Immunol. 124(5):1099-1105(2009)
Radhakrishnan, Y., et al. Biol. Reprod. 81(4):647-656(2009)
Schiemann, F., et al. J. Immunol. 183(4):2223-2231(2009)
Wei, Z.Y., et al. Fa Yi Xue Za Zhi 25(3):164-167(2009)

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$ 295.00
$ 99.00
Cat# AP12270b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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