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GBA3 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - GBA3 Antibody (C-term) AP12289B
    GBA3 Antibody (C-term) (Cat. #AP12289b) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the GBA3 antibody detected the GBA3 protein (arrow).
  • IHC-P - GBA3 Antibody (C-term) AP12289B
    GBA3 Antibody (C-term) (Cat. #AP12289b)immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of GBA3 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9H227
Other Accession NP_001121904.1, NP_066024.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 53696 Da
Antigen Region 296-325 aa
Additional Information
Gene ID 57733
Other Names Cytosolic beta-glucosidase, Cytosolic beta-glucosidase-like protein 1, GBA3, CBG, CBGL1
Target/Specificity This GBA3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 296-325 amino acids from the C-terminal region of human GBA3.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGBA3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GBA3
Synonyms CBG, CBGL1
Function Glycosidase probably involved in the intestinal absorption and metabolism of dietary flavonoid glycosides. Able to hydrolyze a broad variety of glycosides including phytoestrogens, flavonols, flavones, flavanones and cyanogens. Possesses beta- glycosylceramidase activity and may be involved in a nonlysosomal catabolic pathway of glycosylceramide.
Cellular Location Cytoplasm, cytosol
Tissue Location Present in small intestine (at protein level). Expressed in liver, small intestine, colon, spleen and kidney Down-regulated in renal cell carcinomas and hepatocellular carcinomas.
Research Areas
Citations (0)

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GBA3, or cytosolic beta-glucosidase (EC, is a predominantly liver enzyme that efficiently hydrolyzes beta-D-glucoside and beta-D-galactoside, but not any known physiologic beta-glycoside, suggesting that it may be involved in detoxification of plant glycosides (de Graaf et al., 2001 [PubMed 11389701]). GBA3 also has significant neutral glycosylceramidase activity (EC, suggesting that it may be involved in a nonlysosomal catabolic pathway of glucosylceramide metabolism (Hayashi et al., 2007 [PubMed 17595169]).


Dekker, N., et al. Blood Cells Mol. Dis. (2010) In press :
Noguchi, J., et al. Biochem. Biophys. Res. Commun. 374(3):549-552(2008)
Hayashi, Y., et al. J. Biol. Chem. 282(42):30889-30900(2007)
Tribolo, S., et al. J. Mol. Biol. 370(5):964-975(2007)
Beutler, E., et al. J. Lab. Clin. Med. 144(2):65-68(2004)

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$ 295.00
$ 99.00
Cat# AP12289B
(40 western blots)
Availability: In Stock
Bulk Size
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