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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   FYB Antibody (C-term)   

FYB Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - FYB Antibody (C-term) AP12307B
    FYB Antibody (C-term) (Cat. #AP12307b) western blot analysis in MDA-MB435 cell line lysates (35ug/lane).This demonstrates the FYB antibody detected the FYB protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O15117
Other Accession NP_955367.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 85387 Da
Antigen Region 646-675 aa
Additional Information
Gene ID 2533
Other Names FYN-binding protein, Adhesion and degranulation promoting adaptor protein, ADAP, FYB-120/130, p120/p130, FYN-T-binding protein, SLAP-130, SLP-76-associated phosphoprotein, FYB, SLAP130
Target/Specificity This FYB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 646-675 amino acids from the C-terminal region of human FYB.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsFYB Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FYB
Synonyms SLAP130
Function Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells. Modulates the expression of interleukin-2 (IL-2). Involved in platelet activation. Prevents the degradation of SKAP1 and SKAP2. May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton.
Cellular Location Cytoplasm. Nucleus
Tissue Location Expressed in hematopoietic tissues such as myeloid and T-cells, spleen and thymus. Not expressed in B-cells, nor in non-lymphoid tissues
Research Areas
Citations (0)

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FYB acts as an adapter protein of the FYN and LCP2 signaling cascades in T cells. Modulates the expression of interleukin-2 (IL-2). Involved in platelet activation. Prevents the degradation of SKAP1 and SKAP2.


Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Srivastava, R., et al. J. Biol. Chem. 285(15):11100-11105(2010)
Lehmann, R., et al. Proteomics 9(23):5288-5295(2009)
Voss, M., et al. BMC Immunol. 10, 53 (2009) :
Burbach, B.J., et al. J. Immunol. 181(7):4840-4851(2008)

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$ 295.00
$ 99.00
Cat# AP12307B
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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