|Application ||WB, IHC-P, FC, E|
|Other Accession||A2AQW0, NP_001001671.3|
|Calculated MW||147437 Da|
|Antigen Region||315-342 aa|
|Other Names||Mitogen-activated protein kinase kinase kinase 15, Apoptosis signal-regulating kinase 3, MAPK/ERK kinase kinase 15, MEK kinase 15, MEKK 15, MAP3K15, ASK3|
|Target/Specificity||This MAP3K15 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 315-342 amino acids from the N-terminal region of human MAP3K15.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MAP3K15 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May function in a signal transduction pathway that is activated by various cell stresses and leads to apoptosis.|
|Tissue Location||Isoform 2 and isoform 3 are widely expressed. Isoform 2 highest levels are observed in fetal brain, and isoform 3 highest levels in pancreas, peripheral blood leukocytes, fetal brain and spleen.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of the mitogen-activated protein kinase (MAPK) family. These family members function in a protein kinase signal transduction cascade, where an activated MAPK kinase kinase (MAP3K) phosphorylates and activates a specific MAPK kinase (MAP2K), which then activates a specific MAPK. This MAP3K protein plays an essential role in apoptotic cell death triggered by cellular stresses. [provided by RefSeq].
Kaji, T., et al. Biochem. Biophys. Res. Commun. 395(2):213-218(2010)
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