|Application ||WB, IHC-P, E|
|Other Accession||Q4R374, NP_001854.1|
|Calculated MW||10192 Da|
|Antigen Region||59-86 aa|
|Other Names||Cytochrome c oxidase subunit 6B1, Cytochrome c oxidase subunit VIb isoform 1, COX VIb-1, COX6B1, COX6B|
|Target/Specificity||This COX6B1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 59-86 amino acids from the C-terminal region of human COX6B1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||COX6B1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Connects the two COX monomers into the physiological dimeric form.|
|Cellular Location||Mitochondrion intermembrane space|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes subunit VIb. Mutations in this gene are associated with severe infantile encephalomyopathy. Three pseudogenes COX6BP-1, COX6BP-2 and COX6BP-3 have been found on chromosomes 7, 17 and 22q13.1-13.2, respectively.
Lazarou, M., et al. FEBS J. 276(22):6701-6713(2009)
Massa, V., et al. Am. J. Hum. Genet. 82(6):1281-1289(2008)
Sirchia, R., et al. Biol. Chem. 388(5):457-465(2007)
Schmidt, T.R., et al. Gene 286(1):13-19(2002)
Taanman, J.W., et al. Hum. Genet. 87(3):325-327(1991)
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