- CITATIONS: 1
|Application ||WB, IHC-P, IF, FC, E|
|Calculated MW||61036 Da|
|Antigen Region||156-185 aa|
|Other Names||UDP-glucuronosyltransferase 2B15, UDPGT 2B15, HLUG4, UDP-glucuronosyltransferase 2B8, UDPGT 2B8, UDPGTh-3, UGT2B15, UGT2B8|
|Target/Specificity||This UGT2B15 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 156-185 amino acids from the Central region of human UGT2B15.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||UGT2B15 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme displays activity toward several classes of xenobiotic substrates, including simple phenolic compounds, 7-hydroxylated coumarins, flavonoids, anthraquinones, and certain drugs and their hydroxylated metabolites. It also catalyzes the glucuronidation of endogenous estrogens and androgens.|
|Cellular Location||Microsome membrane; Single- pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein|
|Tissue Location||Expressed in many tissues. Present in liver, prostate and testis.|
Provided below are standard protocols that you may find useful for product applications.
The UGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. UGT2B8 demonstrates reactivity with estriol. See UGT2B4 (MIM 600067).
Yong, M., et al. Cancer Epidemiol. Biomarkers Prev. 19(2):537-546(2010)
Sun, C., et al. Hum. Mutat. 31(1):99-107(2010)
Ross, C.J., et al. Nat. Genet. 41(12):1345-1349(2009)
He, X., et al. Br J Clin Pharmacol 68(5):721-730(2009)
Holmes, M.V., et al. PLoS ONE 4 (12), E7960 (2009) :
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