- CITATIONS: 1
|Application ||WB, IHC-P, E|
|Other Accession||Q6NXL6, Q8WP32|
|Calculated MW||86693 Da|
|Antigen Region||524-555 aa|
|Other Names||Sentrin-specific protease 5, Sentrin/SUMO-specific protease SENP5, SENP5|
|Target/Specificity||This SENP5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 524-555 amino acids from the C-terminal region of human SENP5.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SENP5 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO3 to its mature form and deconjugation of SUMO2 and SUMO3 from targeted proteins. Has weak proteolytic activity against full-length SUMO1 or SUMO1 conjugates. Required for cell division.|
|Cellular Location||Nucleus, nucleolus|
Provided below are standard protocols that you may find useful for product applications.
SENP5 is a protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO3 to its conjugatable mature form and deconjugation of SUMO2 and SUMO3 from targeted substrates. This protein has weak proteolytic activity against full-length SUMO1 or SUMO1 conjugates. SENP5 is required for cell division.
Strausberg, R.L., et al., Proc. Natl. Acad. Sci. U.S.A. 99(26):16899-16903 (2002).
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