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SLC12A6 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - SLC12A6 Antibody (N-term) AP12382a
    SLC12A6 Antibody (N-term) (Cat. #AP12382a) western blot analysis in ZR-75-1 cell line lysates (35ug/lane).This demonstrates the SLC12A6 antibody detected the SLC12A6 protein (arrow).
  • IHC-P - SLC12A6 Antibody (N-term) AP12382a
    SLC12A6 Antibody (N-term) (Cat. #AP12382a)immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of SLC12A6 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9UHW9
Other Accession NP_598408.1, NP_005126.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 127617 Da
Antigen Region 13-42 aa
Additional Information
Gene ID 9990
Other Names Solute carrier family 12 member 6, Electroneutral potassium-chloride cotransporter 3, K-Cl cotransporter 3, SLC12A6, KCC3
Target/Specificity This SLC12A6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 13-42 amino acids from the N-terminal region of human SLC12A6.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSLC12A6 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SLC12A6
Synonyms KCC3
Function Mediates electroneutral potassium-chloride cotransport. May be activated by cell swelling. May contribute to cell volume homeostasis in single cells.
Cellular Location Basolateral cell membrane; Multi-pass membrane protein
Tissue Location Highly expressed in heart, brain and kidney. Detected at lower levels in skeletal muscle, placenta, lung and pancreas. Detected in umbilical vein endothelial cells. Isoform 2 is more abundant in kidney. Isoform 5 is testis specific Expressed in the proximal tubule of the kidney (at protein level)
Research Areas
Citations (0)

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This gene is a member of the K-Cl cotransporter (KCC) family. K-Cl cotransporters are integral membrane proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. The proteins encoded by this gene are activated by cell swelling induced by hypotonic conditions. Alternate splicing results in multiple transcript variants encoding different isoforms. Mutations in this gene are associated with agenesis of the corpus callosum with peripheral neuropathy.


Rinehart, J., et al. Cell 138(3):525-536(2009)
Rudnik-Schoneborn, S., et al. Neuropediatrics 40(3):129-133(2009)
de Krom, M., et al. Biol. Psychiatry 65(7):625-630(2009)
Moser, D., et al. Neuropsychopharmacology 34(2):458-467(2009)
Salin-Cantegrel, A., et al. Hum. Mol. Genet. 17(17):2703-2711(2008)

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Cat# AP12382a
(40 western blots)
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