|Application ||WB, IHC-P, E|
|Other Accession||NP_598408.1, NP_005126.1|
|Calculated MW||127617 Da|
|Antigen Region||13-42 aa|
|Other Names||Solute carrier family 12 member 6, Electroneutral potassium-chloride cotransporter 3, K-Cl cotransporter 3, SLC12A6, KCC3|
|Target/Specificity||This SLC12A6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 13-42 amino acids from the N-terminal region of human SLC12A6.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SLC12A6 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Mediates electroneutral potassium-chloride cotransport. May be activated by cell swelling. May contribute to cell volume homeostasis in single cells.|
|Cellular Location||Basolateral cell membrane; Multi-pass membrane protein|
|Tissue Location||Highly expressed in heart, brain and kidney. Detected at lower levels in skeletal muscle, placenta, lung and pancreas. Detected in umbilical vein endothelial cells. Isoform 2 is more abundant in kidney. Isoform 5 is testis specific Expressed in the proximal tubule of the kidney (at protein level)|
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Provided below are standard protocols that you may find useful for product applications.
This gene is a member of the K-Cl cotransporter (KCC) family. K-Cl cotransporters are integral membrane proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. The proteins encoded by this gene are activated by cell swelling induced by hypotonic conditions. Alternate splicing results in multiple transcript variants encoding different isoforms. Mutations in this gene are associated with agenesis of the corpus callosum with peripheral neuropathy.
Rinehart, J., et al. Cell 138(3):525-536(2009)
Rudnik-Schoneborn, S., et al. Neuropediatrics 40(3):129-133(2009)
de Krom, M., et al. Biol. Psychiatry 65(7):625-630(2009)
Moser, D., et al. Neuropsychopharmacology 34(2):458-467(2009)
Salin-Cantegrel, A., et al. Hum. Mol. Genet. 17(17):2703-2711(2008)
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