|Application ||WB, IHC-P, E|
|Other Accession||NP_002233.2, NP_001165887.1|
|Calculated MW||40530 Da|
|Antigen Region||67-95 aa|
|Other Names||Inward rectifier potassium channel 13, Inward rectifier K(+) channel Kir71, Potassium channel, inwardly rectifying subfamily J member 13, KCNJ13|
|Target/Specificity||This KCNJ13 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 67-95 amino acids from the N-terminal region of human KCNJ13.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||KCNJ13 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ13 has a very low single channel conductance, low sensitivity to block by external barium and cesium, and no dependence of its inward rectification properties on the internal blocking particle magnesium.|
|Cellular Location||Membrane; Multi-pass membrane protein.|
|Tissue Location||Predominantly expressed in small intestine. Expression is also detected in stomach, kidney, and all central nervous system regions tested with the exception of spinal cord|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the inwardly rectifying potassium channel family of proteins. Members of this family form ion channel pores that allow potassium ions to pass into a cell. The encoded protein belongs to a subfamily of low signal channel conductance proteins that have a low dependence on potassium concentration. Mutations in this gene are associated with snowflake vitreoretinal degeneration. Alternate splicing results in multiple transcript variants.
Zhang, W., et al. Biochem. Biophys. Res. Commun. 377(3):981-986(2008)
Ji, W., et al. Nat. Genet. 40(5):592-599(2008)
Hughes, B.A., et al. Am. J. Physiol., Cell Physiol. 294 (2), C423-C431 (2008) :
Hejtmancik, J.F., et al. Am. J. Hum. Genet. 82(1):174-180(2008)
Yang, D., et al. Exp. Eye Res. 86(1):81-91(2008)
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