|Application ||WB, E|
|Other Accession||Q66J90, Q8CFT2, Q5F3P8, Q1LY77, NP_055863.1|
|Predicted||Human, Zebrafish, Chicken, Xenopus|
|Calculated MW||212803 Da|
|Antigen Region||1806-1839 aa|
|Other Names||Histone-lysine N-methyltransferase SETD1B, Lysine N-methyltransferase 2G, SET domain-containing protein 1B, hSET1B, SETD1B, KIAA1076, KMT2G, SET1B|
|Target/Specificity||This SET1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1806-1839 amino acids from the C-terminal region of human SET1B.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SET1B Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||KIAA1076, KMT2G, SET1B|
|Function||Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys- 9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. The non-overalpping localization with SETD1A suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression. Specifically tri-methylates 'Lys-4' of histone H3 in vitro.|
|Cellular Location||Nucleus speckle. Chromosome. Note=Localizes to a largely non- overlapping set of euchromatic nuclear speckles with SETD1A, suggesting that SETD1A and SET1B each bind to a unique set of target genes|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
SET1B is a component of a histone methyltransferase complex that produces trimethylated histone H3 at Lys4 (Lee et al., 2007 [PubMed 17355966]).
Wu, M., et al. Mol. Cell. Biol. 28(24):7337-7344(2008)
Lee, J.H., et al. Mol. Cell. Biol. 28(2):609-618(2008)
Lee, J.H., et al. J. Biol. Chem. 282(18):13419-13428(2007)
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