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> home > Products > Primary Antibodies > Antibody Collections > Catalog Updated > SET1B Antibody (C-term)
SET1B Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
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- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9UPS6 |
| Other Accession | Q66J90, Q8CFT2, Q5F3P8, Q1LY77, NP_055863.1 |
| Reactivity | Mouse |
| Predicted | Zebrafish, Chicken, Xenopus |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 212803 Da |
| Antigen Region | 1806-1839 aa |
| Gene ID | 23067 |
|---|---|
| Other Names | Histone-lysine N-methyltransferase SETD1B, Lysine N-methyltransferase 2G, SET domain-containing protein 1B, hSET1B, SETD1B, KIAA1076, KMT2G, SET1B |
| Target/Specificity | This SET1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1806-1839 amino acids from the C-terminal region of human SET1B. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SET1B Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SETD1B |
|---|---|
| Synonyms | KIAA1076, KMT2G, SET1B |
| Function | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism (PubMed:17355966, PubMed:25561738). Part of chromatin remodeling machinery, forms H3K4me1, H3K4me2 and H3K4me3 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17355966, PubMed:25561738). Plays an essential role in regulating the transcriptional programming of multipotent hematopoietic progenitor cells and lymphoid lineage specification during hematopoiesis (By similarity). |
| Cellular Location | Nucleus. Nucleus speckle. Chromosome. Cytoplasm Note=Localizes to a largely non-overlapping set of euchromatic nuclear speckles with SETD1A, suggesting that SETD1A and SET1B each bind to a unique set of target genes (Probable) (PubMed:17355966). Predominantly nuclear (PubMed:38003223). |
Research Areas
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$ 385.00
Cat# AP12413b
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