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SET1B Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - SET1B Antibody (C-term) AP12413b
    SET1B Antibody (C-term) (Cat. #AP12413b) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the SET1B antibody detected the SET1B protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q9UPS6
Other Accession Q66J90, Q8CFT2, Q5F3P8, Q1LY77, NP_055863.1
Reactivity Mouse
Predicted Zebrafish, Chicken, Xenopus
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 212803 Da
Antigen Region 1806-1839 aa
Additional Information
Gene ID 23067
Other Names Histone-lysine N-methyltransferase SETD1B, Lysine N-methyltransferase 2G, SET domain-containing protein 1B, hSET1B, SETD1B, KIAA1076, KMT2G, SET1B
Target/Specificity This SET1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1806-1839 amino acids from the C-terminal region of human SET1B.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSET1B Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SETD1B
Synonyms KIAA1076, KMT2G, SET1B
Function Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys- 9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. The non-overlapping localization with SETD1A suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression. Specifically tri-methylates 'Lys-4' of histone H3 in vitro.
Cellular Location Nucleus speckle. Chromosome. Note=Localizes to a largely non- overlapping set of euchromatic nuclear speckles with SETD1A, suggesting that SETD1A and SET1B each bind to a unique set of target genes
Citations (0)

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Background

SET1B is a component of a histone methyltransferase complex that produces trimethylated histone H3 at Lys4 (Lee et al., 2007 [PubMed 17355966]).

References

Wu, M., et al. Mol. Cell. Biol. 28(24):7337-7344(2008)
Lee, J.H., et al. Mol. Cell. Biol. 28(2):609-618(2008)
Lee, J.H., et al. J. Biol. Chem. 282(18):13419-13428(2007)

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Discontinued
Cat# AP12413b
Size:
(40 western blots)
Alternative Products:

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