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WDR34 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - WDR34 Antibody (Center) AP12421C
    WDR34 Antibody (Center) (Cat. #AP12421c) western blot analysis in SK-BR-3 cell line lysates (35ug/lane).This demonstrates the WDR34 antibody detected the WDR34 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q96EX3
Other Accession NP_443076.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 57801 Da
Antigen Region 305-334 aa
Additional Information
Gene ID 89891
Other Names WD repeat-containing protein 34, WDR34
Target/Specificity This WDR34 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 305-334 amino acids from the Central region of human WDR34.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsWDR34 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name WDR34
Function Critical for ciliary functions, essential to normal development and survival, most probably as a previously unrecognized component of the mammalian dynein-motor-based intraflagellar transport (IFT) machinery. Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Inhibits the MAP3K7-induced NF-kappa-B activation pathway. Inhibits MAP3K7 phosphorylation at 'Thr-184' and 'Thr-187' upon Il-1 beta stimulation.
Cellular Location Cytoplasm. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, cilium axoneme. Note=Concentrates around the centrioles and basal bodies also showing axonemal staining
Tissue Location Expressed in several cell lines (at protein level).
Research Areas
Citations (0)

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This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation.


Gao, D., et al. Cell. Mol. Life Sci. 66(15):2573-2584(2009)
Humphray, S.J., et al. Nature 429(6990):369-374(2004)

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$ 295.00
$ 99.00
Cat# AP12421C
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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