|Application ||WB, FC, E|
|Other Accession||Q8R0J7, NP_078943.1|
|Calculated MW||31307 Da|
|Antigen Region||99-127 aa|
|Other Names||Vacuolar protein sorting-associated protein 37B, hVps37B, ESCRT-I complex subunit VPS37B, VPS37B|
|Target/Specificity||This VPS37B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 99-127 amino acids from the Central region of human VPS37B.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||VPS37B Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.|
|Cellular Location||Late endosome membrane; Peripheral membrane protein. Note=Recruited to the endosomal membrane in a VPS4A-dependent fashion|
|Tissue Location||Widely expressed. Expressed in macrophages and lymphocytes.|
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Provided below are standard protocols that you may find useful for product applications.
VPS37B is component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Stuchell, M.D., et al. J. Biol. Chem. 279(34):36059-36071(2004)
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