|Application ||WB, IHC-P, E|
|Other Accession||NP_006703.1, NP_148936.2|
|Calculated MW||61104 Da|
|Antigen Region||395-424 aa|
|Other Names||Fas-activated serine/threonine kinase, FAST kinase, FASTK|
|Target/Specificity||This FASTK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 395-424 amino acids from the C-terminal region of human FASTK.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FASTK Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Phosphorylates the splicing regulator TIA1, thereby promoting the inclusion of FAS exon 6, which leads to an mRNA encoding a pro-apoptotic form of the receptor.|
|Cellular Location||Isoform 4: Mitochondrion matrix. Note=Colocalizes with mitochondrial RNA granules.|
|Tissue Location||Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase was shown to be activated rapidly during Fas-mediated apoptosis in Jurkat cells. In response to Fas receptor ligation, it phosphorylates TIA1, an apoptosis-promoting nuclear RNA-binding protein. The encoded protein is a strong inducer of lymphocyte apoptosis. Two transcript variants encoding different isoforms have been found for this gene. Other variants exist, but their full-length natures have not yet been determined.
Simarro, M., et al. J. Immunol. 184(9):5325-5332(2010)
de Krom, M., et al. Biol. Psychiatry 65(7):625-630(2009)
Simarro, M., et al. Proc. Natl. Acad. Sci. U.S.A. 104(27):11370-11375(2007)
Wu, C., et al. Proteomics 7(11):1775-1785(2007)
Izquierdo, J.M., et al. J. Biol. Chem. 282(3):1539-1543(2007)
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