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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   FASTK Antibody (C-term)   

FASTK Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - FASTK Antibody (C-term) AP12464b
    Western blot analysis of FASTK (arrow) using rabbit polyclonal FASTK Antibody (C-term) (Cat. #AP12464b). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the FASTK gene.
  • IHC-P - FASTK Antibody (C-term) AP12464b
    FASTK Antibody (C-term) (Cat. #AP12464b)immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of FASTK Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q14296
Other Accession NP_006703.1, NP_148936.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 61104 Da
Antigen Region 395-424 aa
Additional Information
Gene ID 10922
Other Names Fas-activated serine/threonine kinase, FAST kinase, FASTK
Target/Specificity This FASTK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 395-424 amino acids from the C-terminal region of human FASTK.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsFASTK Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function Phosphorylates the splicing regulator TIA1, thereby promoting the inclusion of FAS exon 6, which leads to an mRNA encoding a pro-apoptotic form of the receptor.
Tissue Location Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas
Research Areas
Citations (0)

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The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase was shown to be activated rapidly during Fas-mediated apoptosis in Jurkat cells. In response to Fas receptor ligation, it phosphorylates TIA1, an apoptosis-promoting nuclear RNA-binding protein. The encoded protein is a strong inducer of lymphocyte apoptosis. Two transcript variants encoding different isoforms have been found for this gene. Other variants exist, but their full-length natures have not yet been determined.


Simarro, M., et al. J. Immunol. 184(9):5325-5332(2010)
de Krom, M., et al. Biol. Psychiatry 65(7):625-630(2009)
Simarro, M., et al. Proc. Natl. Acad. Sci. U.S.A. 104(27):11370-11375(2007)
Wu, C., et al. Proteomics 7(11):1775-1785(2007)
Izquierdo, J.M., et al. J. Biol. Chem. 282(3):1539-1543(2007)

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$ 295.00
$ 99.00
Cat# AP12464b
(40 western blots)
Availability: In Stock
Bulk Size
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