|Application ||WB, IHC-P, E|
|Calculated MW||67764 Da|
|Antigen Region||145-171 aa|
|Other Names||Syntaxin-binding protein 3, Platelet Sec1 protein, PSP, Protein unc-18 homolog 3, Unc18-3, Protein unc-18 homolog C, Unc-18C, STXBP3|
|Target/Specificity||This STXBP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 145-171 amino acids from the Central region of human STXBP3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||STXBP3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Together with STX4 and VAMP2, may play a role in insulin-dependent movement of GLUT4 and in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes.|
|Cellular Location||Cytoplasm, cytosol. Cell membrane. Note=In platelets, predominantly cytosolic. Low amounts membrane-associated|
|Tissue Location||Megakaryocytes and platelets.|
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Provided below are standard protocols that you may find useful for product applications.
Together with STX4 and VAMP2, STXBP3 may play a role in insulin-dependent movement of GLUT4 and in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes (By similarity).
Bostrom, P., et al. Diabetes 59(8):1870-1878(2010)
Ban, H.J., et al. BMC Genet. 11, 26 (2010) :
Brochetta, C., et al. Biochim. Biophys. Acta 1783(10):1781-1791(2008)
Smithers, N.P., et al. J. Recept. Signal Transduct. Res. 28(6):581-589(2008)
Fu, J., et al. J. Biol. Chem. 280(5):3178-3184(2005)
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