|Application ||WB, IHC-P, FC, E|
|Calculated MW||23977 Da|
|Antigen Region||148-177 aa|
|Other Names||WAP four-disulfide core domain protein 1, Prostate stromal protein ps20, ps20 growth inhibitor, WFDC1, PS20|
|Target/Specificity||This WFDC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 148-177 amino acids from the C-terminal region of human WFDC1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||WFDC1 Antibody (C-term H163) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Has growth inhibitory activity.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the WAP-type four disulfide core domain family. The WAP-type four-disulfide core domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. The encoded protein shares 81% amino acid identity with the rat ps20 protein, which was originally identified as a secreted growth inhibitor. This gene is mapped to chromosome 16q24, an area of frequent loss of heterozygosity in cancers, including prostate, breast and hepatocellular cancers and Wilms' tumor. Owing to its location and a possible growth inhibitory property of its gene product, this gene is suggested to be a tumor suppressor gene.
Briggs, F.B., et al. Genes Immun. 11(3):199-208(2010)
Madar, S., et al. Carcinogenesis 30(1):20-27(2009)
Liu, S., et al. Clin. Exp. Metastasis 26(7):739-749(2009)
Alvarez, R., et al. J. Virol. 82(1):471-486(2008)
Watson, J.E., et al. Prostate 61(2):192-199(2004)
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