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HYAL2 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - HYAL2 Antibody (Center) AP12491c
    Western blot analysis of HYAL2 Antibody (Center) Pab (Cat. #AP12491c) pre-incubated without(lane 1) and with(lane 2) blocking peptide in Hela cell line lysate. HYAL2 Antibody (Center) (arrow) was detected using the purified Pab.
  • IHC-P - HYAL2 Antibody (Center) AP12491c
    HYAL2 Antibody (Center) (Cat. #AP12491c)immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of HYAL2 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q12891
Other Accession NP_003764.3, NP_149348.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 53860 Da
Antigen Region 128-157 aa
Additional Information
Gene ID 8692
Other Names Hyaluronidase-2, Hyal-2, Hyaluronoglucosaminidase-2, Lung carcinoma protein 2, LuCa-2, HYAL2, LUCA2
Target/Specificity This HYAL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 128-157 amino acids from the Central region of human HYAL2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsHYAL2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HYAL2
Synonyms LUCA2
Function Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product which is further hydrolyzed by sperm hyaluronidase to give small oligosaccharides. Displays very low levels of activity. Associates with and negatively regulates MST1R.
Cellular Location Cell membrane; Lipid-anchor, GPI-anchor
Tissue Location Widely expressed. No expression detected in adult brain.
Research Areas
Citations (0)

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This gene encodes a weak acid-active hyaluronidase. The encoded protein is similar in structure to other more active hyaluronidases. Hyaluronidases degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan and fragments of hyaluronan are thought to be involved in cell proliferation, migration and differentiation. Although it was previously thought to be a lysosomal hyaluronidase that is active at a pH below 4, the encoded protein is likely a GPI-anchored cell surface protein. This hyaluronidase serves as a receptor for the oncogenic virus Jaagsiekte sheep retrovirus. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. This gene encodes two alternatively spliced transcript variants which differ only in the 5' UTR.


Monzon, M.E., et al. J. Biol. Chem. 285(34):26126-26134(2010)
Tzuman, Y.C., et al. Neoplasia 12(1):51-60(2010)
de la Motte, C., et al. Am. J. Pathol. 174(6):2254-2264(2009)
Nykopp, T.K., et al. BMC Cancer 9, 143 (2009) :
Miller, A.D., et al. Osteoarthr. Cartil. 14(12):1315-1317(2006)

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$ 295.00
$ 99.00
Cat# AP12491c
(40 western blots)
Availability: In Stock
Bulk Size
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