|Application ||WB, IHC-P, E|
|Other Accession||NP_003764.3, NP_149348.2|
|Calculated MW||53860 Da|
|Antigen Region||128-157 aa|
|Other Names||Hyaluronidase-2, Hyal-2, Hyaluronoglucosaminidase-2, Lung carcinoma protein 2, LuCa-2, HYAL2, LUCA2|
|Target/Specificity||This HYAL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 128-157 amino acids from the Central region of human HYAL2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||HYAL2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product which is further hydrolyzed by sperm hyaluronidase to give small oligosaccharides. Displays very low levels of activity. Associates with and negatively regulates MST1R.|
|Cellular Location||Cell membrane; Lipid-anchor, GPI-anchor|
|Tissue Location||Widely expressed. No expression detected in adult brain.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a weak acid-active hyaluronidase. The encoded protein is similar in structure to other more active hyaluronidases. Hyaluronidases degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan and fragments of hyaluronan are thought to be involved in cell proliferation, migration and differentiation. Although it was previously thought to be a lysosomal hyaluronidase that is active at a pH below 4, the encoded protein is likely a GPI-anchored cell surface protein. This hyaluronidase serves as a receptor for the oncogenic virus Jaagsiekte sheep retrovirus. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. This gene encodes two alternatively spliced transcript variants which differ only in the 5' UTR.
Monzon, M.E., et al. J. Biol. Chem. 285(34):26126-26134(2010)
Tzuman, Y.C., et al. Neoplasia 12(1):51-60(2010)
de la Motte, C., et al. Am. J. Pathol. 174(6):2254-2264(2009)
Nykopp, T.K., et al. BMC Cancer 9, 143 (2009) :
Miller, A.D., et al. Osteoarthr. Cartil. 14(12):1315-1317(2006)
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