|Application ||WB, IHC-P, E|
|Calculated MW||79686 Da|
|Antigen Region||341-370 aa|
|Other Names||Peroxisomal multifunctional enzyme type 2, MFE-2, 17-beta-hydroxysteroid dehydrogenase 4, 17-beta-HSD 4, D-bifunctional protein, DBP, Multifunctional protein 2, MPF-2, (3R)-hydroxyacyl-CoA dehydrogenase, 111n12, Enoyl-CoA hydratase 2, 3-alpha, 7-alpha, 12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase, HSD17B4, EDH17B4|
|Target/Specificity||This HSD17B4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 341-370 amino acids from the Central region of human HSD17B4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||HSD17B4 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Bifunctional enzyme acting on the peroxisomal beta- oxidation pathway for fatty acids. Catalyzes the formation of 3- ketoacyl-CoA intermediates from both straight-chain and 2-methyl- branched-chain fatty acids.|
|Tissue Location||Present in many tissues with highest concentrations in liver, heart, prostate and testis|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a bifunctional enzyme that is involved in the peroxisomal beta-oxidation pathway for fatty acids. It also acts as a catalyst for the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids. Defects in this gene that affect the peroxisomal fatty acid beta-oxidation activity are a cause of D-bifunctional protein deficiency (DBPD). An apparent pseudogene of this gene is present on chromosome 8. [provided by RefSeq].
Canzian, F., et al. Hum. Mol. Genet. 19(19):3873-3884(2010)
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Kashiwayama, Y., et al. J. Biol. Chem. 285(34):26315-26325(2010)
Pierce, S.B., et al. Am. J. Hum. Genet. 87(2):282-288(2010)
Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010)
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