|Application ||WB, E|
|Calculated MW||50560 Da|
|Antigen Region||257-286 aa|
|Other Names||ERBB receptor feedback inhibitor 1, Mitogen-inducible gene 6 protein, MIG-6, ERRFI1, MIG6|
|Target/Specificity||This ERRFI1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 257-286 amino acids from the Central region of human ERRFI1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ERRFI1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Negative regulator of EGFR signaling in skin morphogenesis. Acts as a negative regulator for several EGFR family members, including ERBB2, ERBB3 and ERBB4. Inhibits EGFR catalytic activity by interfering with its dimerization. Inhibits autophosphorylation of EGFR, ERBB2 and ERBB4. Important for normal keratinocyte proliferation and differentiation. Plays a role in modulating the response to steroid hormones in the uterus. Required for normal response to progesterone in the uterus and for fertility. Mediates epithelial estrogen responses in the uterus by regulating ESR1 levels and activation. Important for regulation of endometrium cell proliferation. Important for normal prenatal and perinatal lung development (By similarity).|
|Cellular Location||Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus Note=Associated with the plasma membrane of basal skin keratinocytes. Translocates into the nucleus of differentiating suprabasal keratinocytes (By similarity).|
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Provided below are standard protocols that you may find useful for product applications.
ERRFI1 is a cytoplasmic protein whose expression is upregulated with cell growth (Wick et al., 1995 [PubMed 7641805]). It shares significant homology with the protein product of rat gene-33, which is induced during cell stress and mediates cell signaling (Makkinje et al., 2000 [PubMed 10749885]; Fiorentino et al., 2000 [PubMed 11003669]).
Frosi, Y., et al. J. Cell Biol. 189(3):557-571(2010)
Ying, H., et al. Proc. Natl. Acad. Sci. U.S.A. 107(15):6912-6917(2010)
Dubois, P.C., et al. Nat. Genet. 42(4):295-302(2010)
Reschke, M., et al. Hepatology 51(4):1383-1390(2010)
Nagashima, T., et al. FEBS J. 276(18):5239-5251(2009)
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