|Application ||WB, IHC-P, E|
|Calculated MW||44340 Da|
|Antigen Region||119-148 aa|
|Other Names||Homeobox protein Hox-B3, Homeobox protein Hox-27, Homeobox protein Hox-2G, HOXB3, HOX2G|
|Target/Specificity||This HOXB3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 119-148 amino acids from the Central region of human HOXB3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||HOXB3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.|
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Provided below are standard protocols that you may find useful for product applications.
This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with a distinct biologic subset of acute myeloid leukemia (AML).
Palakurthy, R.K., et al. Mol. Cell 36(2):219-230(2009)
Ferrai, C., et al. Mol. Biol. Cell 20(15):3543-3551(2009)
Chung, N., et al. Mol. Biol. Rep. 36(2):227-235(2009)
Speleman, F., et al. Leukemia 19(3):358-366(2005)
Roche, J., et al. Leukemia 18(6):1059-1063(2004)
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