|Application ||WB, E|
|Calculated MW||133378 Da|
|Antigen Region||464-493 aa|
|Other Names||Tubulin polyglutamylase TTLL4, 6---, Tubulin--tyrosine ligase-like protein 4, TTLL4, KIAA0173|
|Target/Specificity||This TTLL4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 464-493 amino acids from the Central region of human TTLL4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TTLL4 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Polyglutamylase which preferentially modifies beta- tubulin and nucleosome assembly proteins NAP1 and NAP2. Involved in the side-chain initiation step of the polyglutamylation reaction rather than in the elongation step (By similarity).|
|Cellular Location||Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body Note=Located in cilia. In some cells, also found in basal bodies (By similarity).|
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Provided below are standard protocols that you may find useful for product applications.
TTLL4 is polyglutamylase which preferentially modifies beta-tubulin and nucleosome assembly proteins NAP1 and NAP2. It is involved in the side-chain initiation step of the polyglutamylation reaction rather than in the elongation step (By similarity).
Trichet, V., et al. Gene 257(1):109-117(2000)
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