|Application ||WB, IHC-P, FC, E|
|Other Accession||NP_001164566.1, NP_065117.1|
|Calculated MW||24549 Da|
|Antigen Region||174-201 aa|
|Other Names||Claudin-2, SP82, CLDN2|
|Target/Specificity||This CLDN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 174-201 amino acids from the C-terminal region of human CLDN2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CLDN2 Antibody (C-term Y195) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity.|
|Cellular Location||Cell junction, tight junction. Cell membrane; Multi-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
This gene product belongs to the claudin protein family whose members have been identified as major integral membrane proteins localized exclusively at tight junctions. Claudins are expressed in an organ-specific manner and regulate tissue-specific physiologic properties of tight junctions. This protein is expressed in the intestine. Alternatively spliced transcript variants with different 5' untranslated region have been found for this gene.
Smith, A.J., et al. J. Acquir. Immune Defic. Syndr. 55(3):306-315(2010)
Kojima, F., et al. Oncol. Rep. 23(4):927-931(2010)
Szakal, D.N., et al. Virchows Arch. 456(3):245-250(2010)
Buchert, M., et al. Proc. Natl. Acad. Sci. U.S.A. 107(6):2628-2633(2010)
Mankertz, J., et al. Cell Tissue Res. 336(1):67-77(2009)
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