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>   home   >   Products   >   Primary Antibodies   >   Cancer   >   IRF4 Antibody (Center)   

IRF4 Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - IRF4 Antibody (Center) AP12637c
    Western blot analysis of IRF4 (arrow) using rabbit polyclonal IRF4 Antibody (Center) (Cat. #AP12637c). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the IRF4 gene.
  • FC - IRF4 Antibody (Center) AP12637c
    IRF4 Antibody (Center) (Cat. #AP12637c) flow cytometric analysis of 293 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q15306
Other Accession NP_001182215.1, NP_002451.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 51772 Da
Antigen Region 164-191 aa
Additional Information
Gene ID 3662
Other Names Interferon regulatory factor 4, IRF-4, Lymphocyte-specific interferon regulatory factor, LSIRF, Multiple myeloma oncogene 1, NF-EM5, IRF4, MUM1
Target/Specificity This IRF4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 164-191 amino acids from the Central region of human IRF4.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsIRF4 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name IRF4
Synonyms MUM1
Function Transcriptional activator. Binds to the interferon- stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 and activation of genes (By similarity).
Cellular Location Nucleus.
Tissue Location Lymphoid cells.
Research Areas
Citations (0)

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The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6;14)(p25;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene.


Ucisik-Akkaya, E., et al. Mol. Hum. Reprod. 16(10):770-777(2010)
Staudt, V., et al. Immunity 33(2):192-202(2010)
Newton-Bishop, J.A., et al. Cancer Epidemiol. Biomarkers Prev. 19(8):2043-2054(2010)
Duffy, D.L., et al. Am. J. Hum. Genet. 87(1):6-16(2010)
Eriksson, N., et al. PLoS Genet. 6 (6), E1000993 (2010) :

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$ 295.00
$ 99.00
Cat# AP12637c
(40 western blots)
Availability: In Stock
Bulk Size
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