ANGPTL7 Antibody (C-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| FC, IHC-P, WB, E |
---|---|
Primary Accession | O43827 |
Other Accession | NP_066969.1 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 40018 Da |
Antigen Region | 315-346 aa |
Gene ID | 10218 |
---|---|
Other Names | Angiopoietin-related protein 7, Angiopoietin-like factor, Angiopoietin-like protein 7, Cornea-derived transcript 6 protein, ANGPTL7, CDT6 |
Target/Specificity | This ANGPTL7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 315-346 amino acids from the C-terminal region of human ANGPTL7. |
Dilution | WB~~1:1000 IHC-P~~1:10~50 FC~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | ANGPTL7 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | ANGPTL7 |
---|---|
Synonyms | CDT6 |
Function | Has a role in the formation and organization of the extracellular matrix. In the eye, it functions as a mediator of dexamethasone-induced matrix deposition in the trabecular meshwork, the tissue responsible for the outflow of the ocular aqueous humor and for the maintenance of intraocular pressure (PubMed:21199193). Is a negative regulator of angiogenesis in the cornea, and plays a major role in maintaining corneal avascularity and transparency (PubMed:25622036). |
Cellular Location | Secreted. |
Tissue Location | Highly expressed in the cornea (at protein level) (PubMed:11682471). Expression is restricted to the stromal layer (PubMed:11682471). Also detected at the junction between the corneal stromal layer and the conjuctiva. Not detected in the sclera (PubMed:11682471). |
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Provided below are standard protocols that you may find useful for product applications.
Background
The function of this protein remains unknown.
References
Kuchtey, J., et al. Invest. Ophthalmol. Vis. Sci. 49(8):3438-3448(2008)
Zhang, Z., et al. Protein Sci. 13(10):2819-2824(2004)
Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
Peek, R., et al. J. Biol. Chem. 277(1):686-693(2002)
Stover, C., et al. Genes Immun. 2(3):119-127(2001)
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