|Application ||WB, E|
|Calculated MW||54405 Da|
|Antigen Region||463-489 aa|
|Other Names||Interferon gamma receptor 1, IFN-gamma receptor 1, IFN-gamma-R1, CDw119, CD119, IFNGR1|
|Target/Specificity||This IFNGR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 463-489 amino acids from the C-terminal region of human IFNGR1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||IFNGR1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Associates with IFNGR2 to form a receptor for the cytokine interferon gamma (IFNG) (PubMed:7615558, PubMed:2971451, PubMed:7617032, PubMed:10986460). Ligand binding stimulates activation of the JAK/STAT signaling pathway (PubMed:7673114).|
|Cellular Location||Cell membrane; Single-pass type I membrane protein|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
This gene (IFNGR1) encodes the ligand-binding chain (alpha) of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. A genetic variation in IFNGR1 is associated with susceptibility to Helicobacter pylori infection. In addition, defects in IFNGR1 are a cause of mendelian susceptibility to mycobacterial disease, also known as familial disseminated atypical mycobacterial infection. [provided by RefSeq].
Silva, L.K., et al. Eur. J. Hum. Genet. 18(11):1221-1227(2010)
Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)
Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010) :
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
de Wit, E., et al. Mamm. Genome (2010) In press :
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.