|Application ||WB, IHC-P, FC, E|
|Other Accession||Q62751, B3VKQ2, Q811J3, NP_004127.1|
|Predicted||Mouse, Pig, Rat|
|Calculated MW||105045 Da|
|Antigen Region||201-230 aa|
|Other Names||Iron-responsive element-binding protein 2, IRE-BP 2, Iron regulatory protein 2, IRP2, IREB2|
|Target/Specificity||This IREB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 201-230 amino acids from the Central region of human IREB2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||IREB2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'- UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA.|
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Provided below are standard protocols that you may find useful for product applications.
IREB2 is a RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA.
Ucisik-Akkaya, E., et al. Mol. Hum. Reprod. 16(10):770-777(2010)
Hansen, H.M., et al. Hum. Mol. Genet. 19(18):3652-3661(2010)
Cho, M.H., et al. Nat. Genet. 42(3):200-202(2010)
Salahudeen, A.A., et al. Science 326(5953):722-726(2009)
DeMeo, D.L., et al. Am. J. Hum. Genet. 85(4):493-502(2009)
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