|Application ||WB, IHC-P, E|
|Other Accession||Q9GKT6, NP_056278.1, NP_001104571.1|
|Calculated MW||18648 Da|
|Antigen Region||76-104 aa|
|Other Names||CB1 cannabinoid receptor-interacting protein 1, CRIP-1, CNRIP1, C2orf32|
|Target/Specificity||This CNRP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 76-104 amino acids from the Central region of human CNRP1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CNRP1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Isoform 1 suppresses cannabinoid receptor CNR1-mediated tonic inhibition of voltage-gated calcium channels. Isoform 2 does not have this effect.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a G-protein coupled receptor which interacts with the C-terminal tail of cannabinoid receptor 1. This receptor plays a role in synaptic plasticity, analgesia, appetite, and neuroprotection. Two transcript variants encoding different isoforms have been described for this gene.
Rose, J. Phd, et al. Mol. Med. (2010) In press :
Gieger, C., et al. PLoS Genet. 4 (11), E1000282 (2008) :
Niehaus, J.L., et al. Mol. Pharmacol. 72(6):1557-1566(2007)
Swick, L., et al. J. Neurochem. 97(5):1447-1455(2006)
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