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HIST1H2BO/HIST1H2BH Antibody (N-term)Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP12711a | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
| AP12711a-ev20 | 20 ug 100 ul | In Stock | $ 95.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
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- Backgrounds
HIST1H2BO/HIST1H2BH Antibody (N-term) - Product info | |
| Application | WB
|
| Primary Accession | P23527 |
| Other Accession | Q5QNW6, Q64525, Q93079, NP_003518.2 |
| Reactivity | Human |
| Predicted | Mouse |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 13906 Da |
HIST1H2BO/HIST1H2BH Antibody (N-term) - Additional info | |
| Gene ID 8348 | |
| Other Names HIST1H2BO; H2BFH; H2BFN; Histone H2B type 1-O; Histone H2B.2; Histone H2B.n | |
| Target/Specificity This HIST1H2BO/HIST1H2BH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human HIST1H2BO/HIST1H2BH. | |
| Dilution WB~~1:100~500WB~~1:1000 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions HIST1H2BO/HIST1H2BH Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. | |
HIST1H2BO/HIST1H2BH Antibody (N-term) - Protein Information | |
| Name HIST1H2BO | |
| Synonyms H2BFH, H2BFN | |
| Function Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling | |
| Cellular Location Nucleus. Chromosome. | |
HIST1H2BO/HIST1H2BH Antibody (N-term) - Related products
HIST1H2BO/HIST1H2BH Antibody (N-term) - Application data
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HIST1H2BO/HIST1H2BH Antibody (N-term) (Cat. #AP12711a) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the HIST1H2BO/HIST1H2BH antibody detected the HIST1H2BO/HIST1H2BH protein (arrow).
HIST1H2BO/HIST1H2BH Antibody (N-term) - Research Areas
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BACKGROUND
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3.
REFERENCES
Kim, S.C., et al. Mol. Cell 23(4):607-618(2006) Beck, H.C., et al. Mol. Cell Proteomics 5(7):1314-1325(2006) Pavri, R., et al. Cell 125(4):703-717(2006) Bonenfant, D., et al. Mol. Cell Proteomics 5(3):541-552(2006) Zhu, B., et al. Mol. Cell 20(4):601-611(2005)
