- CITATIONS: 1
|Application ||WB, IHC-P, E|
|Calculated MW||64831 Da|
|Antigen Region||1-30 aa|
|Other Names||Solute carrier family 23 member 1, Na(+)/L-ascorbic acid transporter 1, Sodium-dependent vitamin C transporter 1, hSVCT1, Yolk sac permease-like molecule 3, SLC23A1, SVCT1, YSPL3|
|Target/Specificity||This SLC23A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human SLC23A1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SLC23A1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate.|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
|Tissue Location||Highly expressed in adult small intestine, kidney, thymus, ovary, colon, prostate and liver, and in fetal kidney, liver and thymus|
Provided below are standard protocols that you may find useful for product applications.
The absorption of vitamin C into the body and its distribution to organs requires two sodium-dependent vitamin C transporters. This gene encodes one of the two transporters. The encoded protein is active in bulk vitamin C transport involving epithelial surfaces. Previously, this gene had an official symbol of SLC23A2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
Timpson, N.J., et al. Am. J. Clin. Nutr. 92(2):375-382(2010)
Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010)
Guey, L.T., et al. Eur. Urol. 57(2):283-292(2010)
Michels, A.J., et al. Am. J. Physiol., Cell Physiol. 297 (5), C1220-C1227 (2009) :
Cahill, L.E., et al. J Nutrigenet Nutrigenomics 2(6):292-301(2009)
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