|Application ||WB, IHC-P, E|
|Calculated MW||74510 Da|
|Antigen Region||439-468 aa|
|Other Names||G-protein-signaling modulator 1, Activator of G-protein signaling 3, GPSM1, AGS3|
|Target/Specificity||This GPSM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 439-468 amino acids from the Central region of human GPSM1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GPSM1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Guanine nucleotide dissociation inhibitor (GDI) which functions as a receptor-independent activator of heterotrimeric G- protein signaling. Keeps G(i/o) alpha subunit in its GDP-bound form thus uncoupling heterotrimeric G-proteins signaling from G protein-coupled receptors. Controls spindle orientation and asymmetric cell fate of cerebral cortical progenitors. May also be involved in macroautophagy in intestinal cells. May play a role in drug addiction.|
|Cellular Location||Cytoplasm, cytosol. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side Cell membrane; Peripheral membrane protein; Cytoplasmic side|
|Tissue Location||Expressed in intestinal cells.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
G proteins propagate intracellular signals initiated by G protein-coupled receptors. GPSM1, a receptor-independent activator of G protein signaling, is one of several factors that influence the basal activity of G protein signaling systems (Pizzinat et al., 2001 [PubMed 11278352]).
Oner, S.S., et al. J. Biol. Chem. 285(44):33949-33958(2010)
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Vural, A., et al. Mol. Cell. Biol. 30(6):1528-1540(2010)
Groves, B., et al. PLoS ONE 5 (1), E8877 (2010) :
An, N., et al. J. Biol. Chem. 283(36):24718-24728(2008)
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