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GPSM1 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - GPSM1 Antibody (Center) AP12738c
    GPSM1 Antibody (Center) (Cat. #AP12738c) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the GPSM1 antibody detected the GPSM1 protein (arrow).
  • IHC-P - GPSM1 Antibody (Center) AP12738c
    GPSM1 Antibody (Center) (Cat. #AP12738c)immunohistochemistry analysis in formalin fixed and paraffin embedded human rectum tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of GPSM1 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q86YR5
Other Accession NP_001139110.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 74510 Da
Antigen Region 439-468 aa
Additional Information
Gene ID 26086
Other Names G-protein-signaling modulator 1, Activator of G-protein signaling 3, GPSM1, AGS3
Target/Specificity This GPSM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 439-468 amino acids from the Central region of human GPSM1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGPSM1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GPSM1
Synonyms AGS3
Function Guanine nucleotide dissociation inhibitor (GDI) which functions as a receptor-independent activator of heterotrimeric G- protein signaling. Keeps G(i/o) alpha subunit in its GDP-bound form thus uncoupling heterotrimeric G-proteins signaling from G protein-coupled receptors. Controls spindle orientation and asymmetric cell fate of cerebral cortical progenitors. May also be involved in macroautophagy in intestinal cells. May play a role in drug addiction.
Cellular Location Cytoplasm, cytosol. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side Cell membrane; Peripheral membrane protein; Cytoplasmic side
Tissue Location Expressed in intestinal cells.
Research Areas
Citations (0)

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G proteins propagate intracellular signals initiated by G protein-coupled receptors. GPSM1, a receptor-independent activator of G protein signaling, is one of several factors that influence the basal activity of G protein signaling systems (Pizzinat et al., 2001 [PubMed 11278352]).


Oner, S.S., et al. J. Biol. Chem. 285(44):33949-33958(2010)
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Vural, A., et al. Mol. Cell. Biol. 30(6):1528-1540(2010)
Groves, B., et al. PLoS ONE 5 (1), E8877 (2010) :
An, N., et al. J. Biol. Chem. 283(36):24718-24728(2008)

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$ 295.00
$ 99.00
Cat# AP12738c
(40 western blots)
Availability: In Stock
Bulk Size
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