|Application ||WB, E|
|Other Accession||NP_001019907.1, NP_079516.1|
|Calculated MW||57235 Da|
|Antigen Region||493-522 aa|
|Other Names||CD276 antigen, 4Ig-B7-H3, B7 homolog 3, B7-H3, Costimulatory molecule, CD276, CD276, B7H3|
|Target/Specificity||This CD276 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 493-522 amino acids from the C-terminal region of human CD276.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CD276 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Ubiquitous but not detectable in peripheral blood lymphocytes or granulocytes. Weakly expressed in resting monocytes. Expressed in dendritic cells derived from monocytes Expressed in epithelial cells of sinonasal tissue. Expressed in extravillous trophoblast cells and Hofbauer cells of the first trimester placenta and term placenta|
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Provided below are standard protocols that you may find useful for product applications.
Costimulatory B7 molecules (e.g., B7-1, or CD80; MIM 112203) signal through CD28 (MIM 186760) family molecules such as CD28, CTLA4 (MIM 123890), and ICOS (MIM 604558).
Zhang, G., et al. J. Immunol. 185(6):3677-3684(2010)
Sun, J., et al. Cancer Immunol. Immunother. 59(8):1163-1171(2010)
Leitner, J., et al. Eur. J. Immunol. 39(7):1754-1764(2009)
Sugamata, R., et al. J. Immunol. 182(11):6799-6806(2009)
Loos, M., et al. BMC Cancer 9, 463 (2009) :
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