|Application ||WB, IHC-P, E|
|Calculated MW||37253 Da|
|Antigen Region||152-180 aa|
|Other Names||Probable tRNA pseudouridine synthase 1, 5499-, TRUB1, PUS4|
|Target/Specificity||This TRUB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 152-180 amino acids from the Central region of human TRUB1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TRUB1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May be responsible for synthesis of pseudouridine from uracil in transfer RNAs.|
|Tissue Location||Highly expressed in heart, skeletal muscle and liver. Expressed at lower levels in lung, small intestine, kidney and spleen.|
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Provided below are standard protocols that you may find useful for product applications.
Pseudouridine is an abundant component of rRNAs and tRNAs and is enzymatically generated by isomerization of uridine by pseudouridine synthase (Zucchini et al., 2003 [PubMed 12736709]).
Grupe, A., et al. Am. J. Hum. Genet. 78(1):78-88(2006)
Deloukas, P., et al. Nature 429(6990):375-381(2004)
Zucchini, C., et al. Int. J. Mol. Med. 11(6):697-704(2003)
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