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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   MATN1 Antibody (C-term)   

MATN1 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - MATN1 Antibody (C-term) AP12822b
    MATN1 Antibody (C-term) (Cat. #AP12822b) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the MATN1 antibody detected the MATN1 protein (arrow).
  • IHC-P - MATN1 Antibody (C-term) AP12822b
    MATN1 Antibody (C-term) (Cat. #AP12822b)immunohistochemistry analysis in formalin fixed and paraffin embedded human skeletal muscle followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of MATN1 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P21941
Other Accession NP_002370.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Antigen Region 376-405 aa
Additional Information
Other Names Cartilage matrix protein, Matrilin-1, MATN1, CMP, CRTM
Target/Specificity This MATN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 376-405 amino acids from the C-terminal region of human MATN1.
Dilution WB~~1:1000
IHC-P~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMATN1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MATN1
Synonyms CMP, CRTM
Function Cartilage matrix protein is a major component of the extracellular matrix of non-articular cartilage. It binds to collagen.
Cellular Location Secreted, extracellular space, extracellular matrix EMBL; M55682; AAB38702.1; -; Genomic_DNA EMBL; M55675; AAB38702.1; JOINED; Genomic_DNA EMBL; M55676; AAB38702.1; JOINED; Genomic_DNA EMBL; M55677; AAB38702.1; JOINED; Genomic_DNA EMBL; M55679; AAB38702.1; JOINED; Genomic_DNA EMBL; M55680; AAB38702.1; JOINED; Genomic_DNA EMBL; M55681; AAB38702.1; JOINED; Genomic_DNA EMBL; M55683; AAA63904.1; -; mRNA EMBL; AK312949; BAG35790.1; -; mRNA EMBL; AL137857; -; NOT_ANNOTATED_CDS; Genomic_DNA CCDS; CCDS336.1; - PIR; A37979; A37979 RefSeq; NP_002370.1; NM_002379.3 UniGene; Hs.150366; - ProteinModelPortal; P21941; - BioGrid; 110316; 4 STRING; 9606.ENSP00000362870; - iPTMnet; P21941; - PhosphoSitePlus; P21941; - BioMuta; MATN1; - DMDM; 115556; - PaxDb; P21941; - PeptideAtlas; P21941; - PRIDE; P21941; - ProteomicsDB; 53943; - DNASU; 4146; - Ensembl; ENST00000373765; ENSP00000362870; ENSG00000162510 GeneID; 4146; - KEGG; hsa:4146; - UCSC; uc001brz.4; human CTD; 4146; - DisGeNET; 4146; - EuPathDB; HostDB:ENSG00000162510.5; - GeneCards; MATN1; - H-InvDB; HIX0000347; - H-InvDB; HIX0028643; - H-InvDB; HIX0029177; - HGNC; HGNC:6907; MATN1 HPA; HPA028580; - MIM; 115437; gene neXtProt; NX_P21941; - OpenTargets; ENSG00000162510; - PharmGKB; PA30650; - eggNOG; ENOG410IR75; Eukaryota eggNOG; ENOG410XSCQ; LUCA GeneTree; ENSGT00920000148956; - HOGENOM; HOG000263415; - HOVERGEN; HBG056906; - InParanoid; P21941; - OMA; YTCACHE; - OrthoDB; EOG091G04O4; - PhylomeDB; P21941; - TreeFam; TF330078; - Reactome; R-HSA-3000178; ECM proteoglycans GeneWiki; MATN1; - GenomeRNAi; 4146; - PRO; PR:P21941; - Proteomes; UP000005640; Chromosome 1 Bgee; ENSG00000162510; - CleanEx; HS_MATN1; - Genevisible; P21941; HS GO; GO:0062023; C:collagen-containing extracellular matrix; IEA:InterPro GO; GO:0031012; C:extracellular matrix; TAS:ProtInc GO; GO:0005576; C:extracellular region; TAS:Reactome GO; GO:0005509; F:calcium ion binding; IEA:InterPro GO; GO:0005201; F:extracellular matrix structural constituent; TAS:ProtInc GO; GO:0030198; P:extracellular matrix organization; TAS:Reactome GO; GO:0003429; P:growth plate cartilage chondrocyte morphogenesis; IEA:Ensembl GO; GO:0065003; P:protein-containing complex assembly; TAS:ProtInc GO; GO:0030500; P:regulation of bone mineralization; IEA:Ensembl Gene3D; 1.20.5.30; -; 1 Gene3D; 3.40.50.410; -; 2 InterPro; IPR001881; EGF-like_Ca-bd_dom InterPro; IPR013032; EGF-like_CS InterPro; IPR000742; EGF-like_dom InterPro; IPR030751; Matrilin-1 InterPro; IPR036337; Matrilin_cc_sf InterPro; IPR019466; Matrilin_coiled-coil_trimer InterPro; IPR002035; VWF_A InterPro; IPR036465; vWFA_dom_sf PANTHER; PTHR44857; PTHR44857; 1 Pfam; PF10393; Matrilin_ccoil; 1 Pfam; PF00092; VWA; 2 SMART; SM00181; EGF; 1 SMART; SM00179; EGF_CA; 1 SMART; SM01279; Matrilin_ccoil; 1 SMART; SM00327; VWA; 2 SUPFAM; SSF53300; SSF53300; 2 SUPFAM; SSF58002; SSF58002; 1 PROSITE; PS01186; EGF_2; 1 PROSITE; PS50234; VWFA; 2 1: Evidence at protein level; Coiled coil; Complete proteome; Disulfide bond; EGF-like domain; Extracellular matrix; Glycoprotein; Reference proteome; Repeat; Secreted; Signal SIGNAL 1 22 CHAIN 23 496 Cartilage matrix protein /FTId=PRO_0000007495 DOMAIN 23 222 VWFA 1. {ECO:0000255|PROSITE- ProRule:PRU00219} DOMAIN 223 263 EGF-like DOMAIN 264 453 VWFA 2. {ECO:0000255|PROSITE- ProRule:PRU00219} COILED 467 495 CARBOHYD 76 76 N-linked (GlcNAc...) asparagine DISULFID 35 221 DISULFID 227 238 DISULFID 234 247 DISULFID 249 262 DISULFID 265 452 CONFLICT 291 291 F -> L (in Ref. 1; AAA63904) SEQUENCE 496 AA; 53701 MW; 2D880A8114C7940F CRC64; MRVLSGTSLM LCSLLLLLQA LCSPGLAPQS RGHLCRTRPT DLVFVVDSSR SVRPVEFEKV KVFLSQVIES LDVGPNATRV GMVNYASTVK QEFSLRAHVS KAALLQAVRR IQPLSTGTMT GLAIQFAITK AFGDAEGGRS RSPDISKVVI VVTDGRPQDS VQDVSARARA SGVELFAIGV GSVDKATLRQ IASEPQDEHV DYVESYSVIE KLSRKFQEAF CVVSDLCATG DHDCEQVCIS SPGSYTCACH EGFTLNSDGK TCNVCSGGGG SSATDLVFLI DGSKSVRPEN FELVKKFISQ IVDTLDVSDK LAQVGLVQYS SSVRQEFPLG RFHTKKDIKA AVRNMSYMEK GTMTGAALKY LIDNSFTVSS GARPGAQKVG IVFTDGRSQD YINDAAKKAK DLGFKMFAVG VGNAVEDELR EIASEPVAEH YFYTADFKTI NQIGKKLQKK ICVEEDPCAC ESLVKFQAKV EGLLQALTRK LEAVSKRLAI LENTVV
Research Areas
Citations (0)

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Background

This gene encodes a member of von Willebrand factor A domain containing protein family. This family of proteins are thought to be involved in the formation of filamentous networks in the extracellular matrices of various tissues. Mutations of this gene have been associated with variety of inherited chondrodysplasias.

References

Jang, J.Y., et al. J. Dent. Res. 89(11):1203-1207(2010)
Fresquet, M., et al. J. Biol. Chem. 285(44):34048-34061(2010)
Wheeler, H.E., et al. PLoS Genet. 5 (10), E1000685 (2009) :
Chen, Z.J., et al. Zhonghua Wai Ke Za Zhi 47(17):1332-1335(2009)
Caporaso, N., et al. PLoS ONE 4 (2), E4653 (2009) :

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$ 295.00
$ 99.00
Cat# AP12822b
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