|Application ||WB, IHC-P, E|
|Calculated MW||62552 Da|
|Antigen Region||17-46 aa|
|Other Names||Phosphatase and actin regulator 3, Scaffold-associated PP1-inhibiting protein, Scapinin, PHACTR3, C20orf101, SCAPIN1|
|Target/Specificity||This PHACTR3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 17-46 amino acids from the N-terminal region of human PHACTR3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PHACTR3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Cellular Location||Nucleus matrix. Note=Localized to the nuclear matrix-intermediate filament scaffold. Isoform 2 is also found in some cytoplasmic extensions|
|Tissue Location||Abundantly expressed in brain. Also found in several tumors such as lung carcinomas, nervous tumors and HL-60 leukemia cells. Isoform 3 is the major form in U-937, GOTO and HL- 60 leukemia cells|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is associated with the nuclear scaffold in proliferating cells. It was found to bind to the catalytic subunit of protein phosphatase-1 (PP1) and inhibit PP1 activity, suggesting that this protein may function as a regulatory subunit of PP1. Alternative splicing at this locus results in several transcript variants encoding different isoforms.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Bankovic, J., et al. Lung Cancer 67(2):151-159(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Sagara, J., et al. PLoS ONE 4 (1), E4247 (2009) :
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