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TAC4 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - TAC4 Antibody (C-term) AP12845B
    TAC4 Antibody (C-term) (Cat. #AP12845b) western blot analysis in MDA-MB435 cell line lysates (35ug/lane).This demonstrates the TAC4 antibody detected the TAC4 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q86UU9
Other Accession NP_001070971.1, NP_001070974.1, NP_001070972.1, NP_733786.2, NP_001070973.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 12305 Da
Antigen Region 85-113 aa
Additional Information
Gene ID 255061
Other Names Tachykinin-4, Preprotachykinin-C, PPT-C, Endokinin-A, EKA, Endokinin-A/B, EKA/B, Endokinin-C, EKC, TAC4 (HGNC:16641)
Target/Specificity This TAC4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 85-113 amino acids from the C-terminal region of human TAC4.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTAC4 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TAC4 (HGNC:16641)
Function Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Endokinin-A induces thermal hyperalgesia and pain-related behavior such as scratching following intrathecal administration in rats. These effects are suppressed by treatment with endokinin- C. Endokinin-A/B reduces arterial blood pressure and increases sperm motility.
Cellular Location Secreted.
Tissue Location Expressed at low levels in the uterus of both pregnant and non-pregnant women. Isoform 1 is found only in the adrenal gland and fetal liver. Isoform 2 is found in heart, liver, bone marrow, prostate, adrenal gland and testis. Isoform 3 and isoform 4 are expressed predominantly in adrenal gland and placenta.
Research Areas
Citations (0)

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This gene is a member of the tachykinin family of neurotransmitter-encoding genes. Tachykinin proteins are cleaved into small, secreted peptides that activate members of a family of receptor proteins. The products of this gene preferentially activate tachykinin receptor 1, and are thought to regulate peripheral endocrine and paracrine functions including blood pressure, the immune system, and endocrine gland secretion. The products of this gene lack a dibasic cleavage site found in other tachykinin proteins. Consequently, the nature of the cleavage products generated in vivo remains to be determined. Multiple transcript variants encoding different isoforms have been found for this gene.


Klassert, T.E., et al. J. Neuroimmunol. 227 (1-2), 202-207 (2010) :
Tran, A.H., et al. Neuropeptides 43(1):1-12(2009)
Cunningham, S., et al. J. Neuroimmunol. 183 (1-2), 208-213 (2007) :
Page, N.M. Vascul. Pharmacol. 45(4):200-208(2006)
Page, N.M. Cell. Mol. Life Sci. 61(13):1652-1663(2004)

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$ 295.00
$ 99.00
Cat# AP12845B
(40 western blots)
Availability: In Stock
Bulk Size
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