|Application ||WB, E|
|Other Accession||NP_001070971.1, NP_001070974.1, NP_001070972.1, NP_733786.2, NP_001070973.1|
|Calculated MW||12305 Da|
|Antigen Region||85-113 aa|
|Other Names||Tachykinin-4, Preprotachykinin-C, PPT-C, Endokinin-A, EKA, Endokinin-A/B, EKA/B, Endokinin-C, EKC, TAC4 (HGNC:16641)|
|Target/Specificity||This TAC4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 85-113 amino acids from the C-terminal region of human TAC4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TAC4 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Endokinin-A induces thermal hyperalgesia and pain-related behavior such as scratching following intrathecal administration in rats. These effects are suppressed by treatment with endokinin- C. Endokinin-A/B reduces arterial blood pressure and increases sperm motility.|
|Tissue Location||Expressed at low levels in the uterus of both pregnant and non-pregnant women. Isoform 1 is found only in the adrenal gland and fetal liver. Isoform 2 is found in heart, liver, bone marrow, prostate, adrenal gland and testis. Isoform 3 and isoform 4 are expressed predominantly in adrenal gland and placenta.|
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Provided below are standard protocols that you may find useful for product applications.
This gene is a member of the tachykinin family of neurotransmitter-encoding genes. Tachykinin proteins are cleaved into small, secreted peptides that activate members of a family of receptor proteins. The products of this gene preferentially activate tachykinin receptor 1, and are thought to regulate peripheral endocrine and paracrine functions including blood pressure, the immune system, and endocrine gland secretion. The products of this gene lack a dibasic cleavage site found in other tachykinin proteins. Consequently, the nature of the cleavage products generated in vivo remains to be determined. Multiple transcript variants encoding different isoforms have been found for this gene.
Klassert, T.E., et al. J. Neuroimmunol. 227 (1-2), 202-207 (2010) :
Tran, A.H., et al. Neuropeptides 43(1):1-12(2009)
Cunningham, S., et al. J. Neuroimmunol. 183 (1-2), 208-213 (2007) :
Page, N.M. Vascul. Pharmacol. 45(4):200-208(2006)
Page, N.M. Cell. Mol. Life Sci. 61(13):1652-1663(2004)
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