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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   CTSK Antibody (Center E112)   

CTSK Antibody (Center E112)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - CTSK Antibody (Center E112) AP12885c
    Western blot analysis of CTSK (arrow) using rabbit polyclonal CTSK Antibody (Center E112) (Cat. #AP12885c). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the CTSK gene.
  • IHC-P - CTSK Antibody (Center E112) AP12885c
    CTSK Antibody (Center E112) (Cat. #AP12885c)immunohistochemistry analysis in formalin fixed and paraffin embedded human skeletal muscle followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of CTSK Antibody (Center E112) for immunohistochemistry. Clinical relevance has not been evaluated.
  • FC - CTSK Antibody (Center E112) AP12885c
    CTSK Antibody (Center E112) (Cat. #AP12885c) flow cytometric analysis of 293 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P43235
Other Accession P61276, Q5E968, NP_000387.1
Reactivity Human
Predicted Bovine, Monkey
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 36966 Da
Antigen Region 97-126 aa
Additional Information
Gene ID 1513
Other Names Cathepsin K, Cathepsin O, Cathepsin O2, Cathepsin X, CTSK, CTSO, CTSO2
Target/Specificity This CTSK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 97-126 amino acids from the Central region of human CTSK.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCTSK Antibody (Center E112) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms CTSO, CTSO2
Function Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation.
Cellular Location Lysosome.
Tissue Location Predominantly expressed in osteoclasts (bones)
Research Areas
Citations (0)

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The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature. This gene may be subject to RNA editing. [provided by RefSeq].


Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Novinec, M., et al. Biochem. J. 429(2):379-389(2010)
Khan, B., et al. J. Investig. Med. 58(5):720-724(2010)
Johnatty, S.E., et al. PLoS Genet. 6 (7), E1001016 (2010) :
Szumilo, J., et al. Folia Histochem. Cytobiol. 47(4):571-578(2009)

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Cat# AP12885c
(40 western blots)
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