|Application ||WB, IHC-P, FC, E|
|Other Accession||P61276, Q5E968, NP_000387.1|
|Calculated MW||36966 Da|
|Antigen Region||97-126 aa|
|Other Names||Cathepsin K, Cathepsin O, Cathepsin O2, Cathepsin X, CTSK, CTSO, CTSO2|
|Target/Specificity||This CTSK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 97-126 amino acids from the Central region of human CTSK.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CTSK Antibody (Center E112) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation.|
|Tissue Location||Predominantly expressed in osteoclasts (bones)|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature. This gene may be subject to RNA editing. [provided by RefSeq].
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Novinec, M., et al. Biochem. J. 429(2):379-389(2010)
Khan, B., et al. J. Investig. Med. 58(5):720-724(2010)
Johnatty, S.E., et al. PLoS Genet. 6 (7), E1001016 (2010) :
Szumilo, J., et al. Folia Histochem. Cytobiol. 47(4):571-578(2009)
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