|Application ||WB, E|
|Other Accession||Q9D8X5, NP_004770.4|
|Calculated MW||33540 Da|
|Antigen Region||33-60 aa|
|Other Names||CCR4-NOT transcription complex subunit 8, CAF1-like protein, CALIFp, CAF2, CCR4-associated factor 8, Caf1b, CNOT8, CALIF, POP2|
|Target/Specificity||This CNOT8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 33-60 amino acids from the N-terminal region of human CNOT8.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CNOT8 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT7. Catalytic component of the CCR4-NOT complex which is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity.|
|Cellular Location||Cytoplasm. Nucleus|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Ubiquitous transcription factor required for a diverse set of processes. The CCR4-NOT complex functions as general transcription regulation complex.
Ruan, L., et al. J. Biol. Chem. 285(36):27624-27631(2010)
Marchese, F.P., et al. J. Biol. Chem. 285(36):27590-27600(2010)
Piao, X., et al. Mol. Cell. Biol. 30(6):1486-1494(2010)
Lau, N.C., et al. Biochem. J. 422(3):443-453(2009)
Aslam, A., et al. Mol. Biol. Cell 20(17):3840-3850(2009)
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