|Application ||WB, E|
|Other Accession||Q9D8X5, NP_004770.4|
|Calculated MW||33540 Da|
|Antigen Region||33-60 aa|
|Other Names||CCR4-NOT transcription complex subunit 8, CAF1-like protein, CALIFp, CAF2, CCR4-associated factor 8, Caf1b, CNOT8, CALIF, POP2|
|Target/Specificity||This CNOT8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 33-60 amino acids from the N-terminal region of human CNOT8.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CNOT8 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT7. Catalytic component of the CCR4-NOT complex which is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity.|
|Cellular Location||Cytoplasm. Nucleus|
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Provided below are standard protocols that you may find useful for product applications.
Ubiquitous transcription factor required for a diverse set of processes. The CCR4-NOT complex functions as general transcription regulation complex.
Ruan, L., et al. J. Biol. Chem. 285(36):27624-27631(2010)
Marchese, F.P., et al. J. Biol. Chem. 285(36):27590-27600(2010)
Piao, X., et al. Mol. Cell. Biol. 30(6):1486-1494(2010)
Lau, N.C., et al. Biochem. J. 422(3):443-453(2009)
Aslam, A., et al. Mol. Biol. Cell 20(17):3840-3850(2009)
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