|Application ||WB, E|
|Calculated MW||36144 Da|
|Antigen Region||7-36 aa|
|Other Names||Corticotropin-releasing factor-binding protein, CRF-BP, CRF-binding protein, Corticotropin-releasing hormone-binding protein, CRH-BP, CRHBP, CRFBP|
|Target/Specificity||This CRHBP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 7-36 amino acids from the N-terminal region of human CRHBP.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CRHBP Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy.|
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Provided below are standard protocols that you may find useful for product applications.
Corticotropin-releasing hormone is a potent stimulator of synthesis and secretion of preopiomelanocortin-derived peptides. Although CRH concentrations in the human peripheral circulation are normally low, they increase throughout pregnancy and fall rapidly after parturition. Maternal plasma CRH probably originates from the placenta. Human plasma contains a CRH-binding protein which inactivates CRH and which may prevent inappropriate pituitary-adrenal stimulation in pregnancy.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Holliday, K.L., et al. J Psychosom Res 68(5):469-474(2010)
Binder, E.B., et al. Arch. Gen. Psychiatry 67(4):369-379(2010)
Bosker, F.J., et al. Mol. Psychiatry (2010) In press :
Tabakoff, B., et al. BMC Biol. 7, 70 (2009) :
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