|Application ||WB, IHC-P, E|
|Other Accession||Q6AYH5, Q99KJ8, Q3ZCF0, NP_006391.1|
|Predicted||Bovine, Mouse, Rat|
|Calculated MW||44231 Da|
|Antigen Region||192-219 aa|
|Other Names||Dynactin subunit 2, 50 kDa dynein-associated polypeptide, Dynactin complex 50 kDa subunit, DCTN-50, p50 dynamitin, DCTN2, DCTN50|
|Target/Specificity||This DCTN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 192-219 amino acids from the Central region of human DCTN2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DCTN2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development.|
|Cellular Location||Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Membrane; Peripheral membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a 50-kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 4-5 copies per dynactin molecule. It contains three short alpha-helical coiled-coil domains that may mediate association with self or other dynactin subunits. It may interact directly with the largest subunit (p150) of dynactin and may affix p150 in place.
Jacquot, G., et al. J. Biol. Chem. 285(30):23019-23031(2010)
Inoue, M., et al. Genes Cells 13(8):905-914(2008)
Maier, K.C., et al. Traffic 9(4):481-491(2008)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Camargo, L.M., et al. Mol. Psychiatry 12(1):74-86(2007)
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