|Application ||WB, IHC-P, E|
|Other Accession||Q8HXX8, Q2KHZ9, NP_000150.1, NP_039663.1|
|Calculated MW||48127 Da|
|Antigen Region||336-365 aa|
|Other Names||Glutaryl-CoA dehydrogenase, mitochondrial, GCD, GCDH|
|Target/Specificity||This GCDH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 336-365 amino acids from the C-terminal region of human GCDH.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GCDH Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor. Isoform Short is inactive.|
|Cellular Location||Mitochondrion matrix.|
|Tissue Location||Isoform 1 and isoform 2 are expressed in fibroblasts and liver|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene belongs to the acyl-CoA dehydrogenase family. It catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor. The enzyme exists in the mitochondrial matrix as a homotetramer of 45-kD subunits. Alternatively spliced transcript variants encoding different isoforms have been identified.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Park, J.D., et al. J. Korean Med. Sci. 25(6):957-960(2010)
Strauss, K.A., et al. Brain 133 (PT 1), 76-92 (2010) :
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Ganesh, S.K., et al. Nat. Genet. 41(11):1191-1198(2009)
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