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SERPINE1 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - SERPINE1 Antibody (Center) AP12919C
    Western blot analysis of SERPINE1 (arrow) using rabbit polyclonal SERPINE1 Antibody (Center) (Cat. #AP12919c). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the SERPINE1 gene.
  • FC - SERPINE1 Antibody (Center) AP12919C
    SERPINE1 Antibody (Center) (Cat. #AP12919c) flow cytometric analysis of U251 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P05121
Other Accession NP_000593.1, NP_001158885.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 45060 Da
Antigen Region 188-216 aa
Additional Information
Gene ID 5054
Other Names Plasminogen activator inhibitor 1, PAI, PAI-1, Endothelial plasminogen activator inhibitor, Serpin E1, SERPINE1, PAI1, PLANH1
Target/Specificity This SERPINE1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 188-216 amino acids from the Central region of human SERPINE1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSERPINE1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms PAI1, PLANH1
Function Serine protease inhibitor. This inhibitor acts as 'bait' for tissue plasminogen activator, urokinase, protein C and matriptase-3/TMPRSS7. Its rapid interaction with PLAT may function as a major control point in the regulation of fibrinolysis.
Cellular Location Secreted.
Tissue Location Found in plasma and platelets and in endothelial, hepatoma and fibrosarcoma cells
Research Areas
Citations (0)

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This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.


Ma, Z., et al. Biochem. Biophys. Res. Commun. 400(4):569-574(2010)
Ince, D.A., et al. Genet Test Mol Biomarkers 14(5):643-647(2010)
Bern, M.M., et al. Clin. Appl. Thromb. Hemost. 16(5):574-578(2010)
Markl, B., et al. J Surg Oncol 102(3):235-241(2010)
de Haas, E.C., et al. Cancer (2010) In press :

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Cat# AP12919C
(40 western blots)
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