|Application ||WB, FC, E|
|Other Accession||NP_000593.1, NP_001158885.1|
|Calculated MW||45060 Da|
|Antigen Region||188-216 aa|
|Other Names||Plasminogen activator inhibitor 1, PAI, PAI-1, Endothelial plasminogen activator inhibitor, Serpin E1, SERPINE1, PAI1, PLANH1|
|Target/Specificity||This SERPINE1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 188-216 amino acids from the Central region of human SERPINE1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SERPINE1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Serine protease inhibitor. This inhibitor acts as 'bait' for tissue plasminogen activator, urokinase, protein C and matriptase-3/TMPRSS7. Its rapid interaction with PLAT may function as a major control point in the regulation of fibrinolysis.|
|Tissue Location||Found in plasma and platelets and in endothelial, hepatoma and fibrosarcoma cells|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Ma, Z., et al. Biochem. Biophys. Res. Commun. 400(4):569-574(2010)
Ince, D.A., et al. Genet Test Mol Biomarkers 14(5):643-647(2010)
Bern, M.M., et al. Clin. Appl. Thromb. Hemost. 16(5):574-578(2010)
Markl, B., et al. J Surg Oncol 102(3):235-241(2010)
de Haas, E.C., et al. Cancer (2010) In press :
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