|Application ||WB, IHC-P, E|
|Other Accession||Q63060, Q64516, Q0IID9, Q14409, NP_976325.1, NP_001121599.1|
|Predicted||Bovine, Mouse, Rat|
|Calculated MW||61245 Da|
|Antigen Region||24-51 aa|
|Other Names||Glycerol kinase, GK, Glycerokinase, ATP:glycerol 3-phosphotransferase, GK|
|Target/Specificity||This GK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 24-51 amino acids from the N-terminal region of human GK.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GK Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Key enzyme in the regulation of glycerol uptake and metabolism.|
|Cellular Location||Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=In sperm and fetal tissues, the majority of the enzyme is bound to mitochondria, but in adult tissues, such as liver found in the cytoplasm|
|Tissue Location||Highly expressed in the liver, kidney and testis. Isoform 2 and isoform 3 are expressed specifically in testis and fetal liver, but not in the adult liver|
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Provided below are standard protocols that you may find useful for product applications.
The product of this gene belongs to the FGGY kinase family of proteins and encodes glycerol kinase. Glycerol kinase is a key enzyme in the regulation of glycerol uptake and metabolism. It catalyzes the phosphorylation of glycerol by ATP, yielding ADP and glycerol-3-phosphate. Defects in this gene are the cause of glycerol kinase deficiency (GKD). Alternatively spliced transcript variants encoding different isoforms have been identified.
Lu, Y., et al. J. Lipid Res. 49(12):2582-2589(2008)
Zhang, Y.H., et al. Pediatr. Res. 59 (4 PT 1), 590-592 (2006) :
Ohira, R.H., et al. Biochem. Biophys. Res. Commun. 331(1):239-246(2005)
Stepanian, S.V., et al. Mol. Genet. Metab. 80(4):412-418(2003)
Hellerud, C., et al. Clin. Chem. Lab. Med. 41(1):46-55(2003)
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