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>   home   >   Products   >   Primary Antibodies   >   Cancer   >   ENOX2 Antibody (N-term)   

ENOX2 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - ENOX2 Antibody (N-term) AP12957a
    ENOX2 Antibody (N-term) (Cat. #AP12957a) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the ENOX2 antibody detected the ENOX2 protein (arrow).
  • IHC-P - ENOX2 Antibody (N-term) AP12957a
    ENOX2 Antibody (N-term) (Cat. #AP12957a)immunohistochemistry analysis in formalin fixed and paraffin embedded human stomach tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of ENOX2 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
  • FC - ENOX2 Antibody (N-term) AP12957a
    ENOX2 Antibody (N-term) (Cat. #AP12957a) flow cytometric analysis of Jurkat cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated donkey-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q16206
Other Accession NP_006366.2, NP_872114.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 70082 Da
Antigen Region 1-30 aa
Additional Information
Gene ID 10495
Other Names Ecto-NOX disulfide-thiol exchanger 2, APK1 antigen, Cytosolic ovarian carcinoma antigen 1, Tumor-associated hydroquinone oxidase, tNOX, Hydroquinone [NADH] oxidase, 1---, Protein disulfide-thiol oxidoreductase, 1---, ENOX2, COVA1
Target/Specificity This ENOX2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human ENOX2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsENOX2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ENOX2
Synonyms COVA1
Function May be involved in cell growth. Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide- thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 22 minutes and play a role in control of the ultradian cellular biological clock.
Cellular Location Cell membrane. Secreted, extracellular space. Note=Extracellular and plasma membrane-associated
Tissue Location Found in the sera of cancer patients with a wide variety of cancers including breast, prostate, lung and ovarian cancers, leukemias, and lymphomas. Not found in the serum of healthy volunteers or patients with disorders other than cancer. Probably shed into serum by cancer cells. Found on the cell borders of renal, kidney and ovarian carcinomas but not on the borders of surrounding non-cancerous stromal cells
Research Areas
Citations (0)

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The protein encoded by this gene is a growth-related cell surface protein. It was identifed because it reacts with the monoclonal antibody KI in cells, such as the ovarian carcinoma line OVCAR-3, also expressing the CAKI surface glycoprotein. The encoded protein has two enzymatic activities: catalysis of hydroquinone or NADH oxidation, and protein disulfide interchange. The two activities alternate with a period length of about 24 minutes. The encoded protein also displays prion-like properties. Two transcript variants encoding different isoforms have been found for this gene.


Morre, D.M., et al. Rejuvenation Res 13 (2-3), 162-164 (2010) :
Morre, D.M., et al. Biofactors 34(3):237-244(2009)
Mao, L.C., et al. FEBS Lett. 582 (23-24), 3445-3450 (2008) :
Liu, S.C., et al. Biochem. Biophys. Res. Commun. 365(4):672-677(2008)
Tang, X., et al. Oncol. Res. 16(12):557-567(2007)

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Cat# AP12957a
(40 western blots)
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