|Application ||WB, IHC-P, E|
|Other Accession||Q9XSC1, NP_003006.2|
|Calculated MW||35563 Da|
|Antigen Region||190-219 aa|
|Other Names||Secreted frizzled-related protein 5, sFRP-5, Frizzled-related protein 1b, FRP-1b, Secreted apoptosis-related protein 3, SARP-3, SFRP5, FRP1B, SARP3|
|Target/Specificity||This SFRP5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 190-219 amino acids from the Central region of human SFRP5.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SFRP5 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP5 may be involved in determining the polarity of photoreceptor, and perhaps, other cells in the retina.|
|Tissue Location||Highly expressed in the retinal pigment epithelium (RPE) and pancreas. Weak expression in heart, liver and muscle.|
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Provided below are standard protocols that you may find useful for product applications.
Secreted frizzled-related protein 5 (SFRP5) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. SFRP5 and SFRP1 may be involved in determining the polarity of photoreceptor cells in the retina. SFRP5 is highly expressed in the retinal pigment epithelium, and moderately expressed in the pancreas. [provided by RefSeq].
Su, H.Y., et al. Int. J. Cancer 127(3):555-567(2010)
Sharma, S., et al. Am. J. Respir. Crit. Care Med. 181(4):328-336(2010)
Jost, E., et al. Cancer Lett. 281(1):24-31(2009)
Zhao, C., et al. BMC Cancer 9, 224 (2009) :
Tanaka, J., et al. Hepatogastroenterology 55(85):1265-1268(2008)
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