|Application ||WB, IHC-P, IF, FC, E|
|Calculated MW||45416 Da|
|Antigen Region||189-218 aa|
|Other Names||Gastric intrinsic factor, Intrinsic factor, IF, INF, GIF, IFMH|
|Target/Specificity||This GIF antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 189-218 amino acids from the Central region of human GIF.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GIF Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Promotes absorption of the essential vitamin cobalamin (Cbl) in the ileum. After interaction with CUBN, the GIF-cobalamin complex is internalized via receptor-mediated endocytosis.|
|Tissue Location||Gastric mucosa.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
This gene is a member of the cobalamin transport protein family. It encodes a glycoprotein secreted by parietal cells of the gastric mucosa and is required for adequate absorption of vitamin B12. Vitamin B12 is necessary for erythrocyte maturation and mutations in this gene may lead to congenital pernicious anemia.
Levine, A.J., et al. Cancer Epidemiol. Biomarkers Prev. 19(7):1812-1821(2010)
Andersen, C.B., et al. Nature 464(7287):445-448(2010)
Ament, A.E., et al. Br. J. Haematol. 144(4):622-624(2009)
Remacha, A.F., et al. Ann. Hematol. 87(7):599-600(2008)
Mathews, F.S., et al. Proc. Natl. Acad. Sci. U.S.A. 104(44):17311-17316(2007)
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