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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   CHTF18 Antibody (C-term)   

CHTF18 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - CHTF18 Antibody (C-term) AP12986B
    CHTF18 Antibody (C-term) (Cat. #AP12986b) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the CHTF18 antibody detected the CHTF18 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8WVB6
Other Accession NP_071375.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 107383 Da
Antigen Region 914-943 aa
Additional Information
Gene ID 63922
Other Names Chromosome transmission fidelity protein 18 homolog, hCTF18, CHL12, CHTF18, C16orf41, CTF18
Target/Specificity This CHTF18 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 914-943 amino acids from the C-terminal region of human CHTF18.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCHTF18 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CHTF18
Synonyms C16orf41, CTF18
Function Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC), which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex binds to single- stranded and primed DNAs and has weak ATPase activity that is stimulated by the presence of primed DNA, replication protein A (RPA) and by proliferating cell nuclear antigen (PCNA). The CTF18- RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA. It also interacts with and stimulates DNA polymerase POLH.
Cellular Location Nucleus. Note=Associates with chromatin during S phase
Research Areas
Citations (0)

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CHTF18, CHTF8 (MIM 613202), and DCC1 (DSCC1; MIM 613203) are components of an alternative replication factor C (RFC) (see MIM 600404) complex that loads PCNA (MIM 176740) onto DNA during S phase of the cell cycle (Merkle et al., 2003 [PubMed 12766176]; Bermudez et al., 2003 [PubMed 12930902]).


Murakami, T., et al. J. Biol. Chem. 285(45):34608-34615(2010)
Farina, A., et al. J. Biol. Chem. 283(30):20925-20936(2008)
Shiomi, Y., et al. J. Biol. Chem. 282(29):20906-20914(2007)
Matsuoka, S., et al. Science 316(5828):1160-1166(2007)
Beausoleil, S.A., et al. Proc. Natl. Acad. Sci. U.S.A. 101(33):12130-12135(2004)

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$ 295.00
$ 99.00
Cat# AP12986B
(40 western blots)
Availability: In Stock
Bulk Size
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