|Application ||WB, IHC-P, E|
|Calculated MW||13530 Da|
|Antigen Region||19-47 aa|
|Other Names||Cytochrome b-c1 complex subunit 7, Complex III subunit 7, Complex III subunit VII, QP-C, Ubiquinol-cytochrome c reductase complex 14 kDa protein, UQCRB, UQBP|
|Target/Specificity||This UQCRB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 19-47 amino acids from the Central region of human UQCRB.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||UQCRB Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This component is involved in redox-linked proton pumping.|
|Cellular Location||Mitochondrion inner membrane.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein which is part of the ubiquinol-cytochrome c oxidoreductase complex which contains ten nuclear-encoded and one mitochondrial-encoded subunits. The encoded protein binds ubiquinone and participates in the transfer of electrons when ubiquinone is bound. Mutations in this gene are associated with mitochondrial complex III deficiency. A pseudogene has been described on the X chromosome.
Wang, L., et al. Cancer Epidemiol. Biomarkers Prev. 17(12):3558-3566(2008)
Haut, S., et al. Hum. Genet. 113(2):118-122(2003)
Malaney, S., et al. Cytogenet. Cell Genet. 73(4):297-299(1996)
Suzuki, H., et al. J. Biol. Chem. 265(14):8159-8163(1990)
Hosokawa, Y., et al. Biochem. Int. 21(1):41-44(1990)
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