|Application ||WB, IHC-P, E|
|Other Accession||Q8K1G0, Q8R373, NP_079045.1|
|Calculated MW||41281 Da|
|Antigen Region||81-110 aa|
|Other Names||CXADR-like membrane protein, Adipocyte adhesion molecule, Coxsackie- and adenovirus receptor-like membrane protein, CAR-like membrane protein, CLMP, ACAM, ASAM|
|Target/Specificity||This ASAM antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 81-110 amino acids from the Central region of human ASAM.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ASAM Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in the cell-cell adhesion. May play a role in adipocyte differentiation and development of obesity. Is required for normal small intestine development.|
|Cellular Location||Cell junction, tight junction. Cell membrane; Single-pass type I membrane protein|
|Tissue Location||Predominantly expressed in epithelial cells within different tissues and in the white adipose tissue Expressed at high levels in small intestine and placenta, at intermediate levels in the heart, skeletal muscle, colon, spleen, kidney and lung and at low levels in the liver and peripheral blood leukocytes. Highly abundant in the intestine during embryo and fetal development (at protein level)|
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Provided below are standard protocols that you may find useful for product applications.
The CTX (see VSIG2, MIM 606011) family of proteins, including ASAM, are type I transmembrane proteins within the Ig superfamily that localize to junctional complexes between endothelial and epithelial cells and may play a role in cell-cell adhesion (Raschperger et al., 2004 [PubMed 14573622]).[supplied by OMIM].
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Kawabata, K., et al. Gene Ther. 14(16):1199-1207(2007)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Eguchi, J., et al. Biochem. J. 387 (PT 2), 343-353 (2005) :
Raschperger, E., et al. J. Biol. Chem. 279(1):796-804(2004)
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